DNA minor groove binders as therapeutic agents
Withers, J. M. and Padroni, G. and Pauff, S. M. and Clark, A. W. and Mackay, S. P. and Burley, G. A.; Atwood, Jerry L., ed. (2017) DNA minor groove binders as therapeutic agents. In: Comprehensive Supramolecular Chemistry II. Elsevier Inc., Amsterdam, pp. 149-178. ISBN 9780128031988 (https://doi.org/10.1016/B978-0-12-409547-2.12561-2)
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This article describes the current state-of-the-art in the development of small- and medium-sized molecules that interact with double-stranded DNA (dsDNA) by minor groove binding. The supramolecular structure of dsDNA is described and how this informs the development of minor groove binding agents. The structure and biological activity of biologically derived, bioinspired, and synthetic minor groove binders (MGBs) are then evaluated. The therapeutic applications of MGBs as antiinfectives and anticancer agents are presented.
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Item type: Book Section ID code: 67137 Dates: DateEvent29 June 2017PublishedNotes: http://dx.doi.org/10.1016/B978-0-12-409547-2.12561-2 Subjects: Science > Chemistry
Medicine > Therapeutics. PharmacologyDepartment: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical SciencesDepositing user: Pure Administrator Date deposited: 05 Mar 2019 11:04 Last modified: 08 Apr 2024 13:52 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/67137