A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan : findings and implications
Saleem, Zikria and Hassali, Mohamed Azmi Ahmad and Versporten, Ann and Godman, Brian and Hashmi, Furqan Khurshid and Goossens, Herman and Saleem, Fahad (2019) A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan : findings and implications. Expert Review of Anti-infective Therapy, 17 (4). pp. 285-293. ISSN 1744-8336
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Abstract
Objectives: In line with the recent global action plan for antimicrobial resistance, this is the first time such a comprehensive antimicrobial point prevalence survey has been undertaken in Pakistan, the sixth most populous country. Methods: This point prevalence survey (PPS) was conducted in 13 hospitals among 7 different cities of Pakistan. The survey included all inpatients receiving an antibiotic on the day of PPS. A web-based application was used for data entry, validation, and reporting as designed by the University of Antwerp (www.global-pps.com). Results: Out of 1954 patients, 1516 (77.6%) were treated with antibiotics. The top three most reported indications for antibiotic use were prophylaxis for obstetrics or gynaecological indications (16.5%), gastrointestinal indications (12.6%) and lower respiratory tract infections (12.0%). The top three most commonly prescribed antibiotics were ceftriaxone (35.0%), metronidazole (16.0%) and ciprofloxacin (6.0%). Out of the total indications, 34.2% of antibiotics were prescribed for community-acquired infections (CAI), 5.9% for healthcare-associated infections (HAI), and 57.4% for either surgical or medical prophylaxis. Of the total use for surgical prophylaxis, 97.4% of antibiotics were given for more than one day. Conclusions: Unnecessary prophylactic antibiotic use is extremely high, and broad-spectrum prescribing is common among hospitals in Pakistan. There is an urgent need to work on the national action plan of Pakistan on antibiotic resistance to address this.
Creators(s): | Saleem, Zikria, Hassali, Mohamed Azmi Ahmad, Versporten, Ann, Godman, Brian, Hashmi, Furqan Khurshid, Goossens, Herman and Saleem, Fahad; | Item type: | Article |
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ID code: | 66848 |
Keywords: | point prevalence survey, antimicrobial prescribing, antimicrobial resistance, hospitals, Pakistan, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all) |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 07 Feb 2019 09:39 |
Last modified: | 12 Feb 2021 03:46 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/66848 |
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