Discovery and recovery of delta p-aminobenzoic acid

Ward, Martin R. and Younis, Shatha and Cruz-Cabeza, Aurora J. and Bull, Craig L. and Funnell, Nicholas P. and Oswald, Iain D. H. (2019) Discovery and recovery of delta p-aminobenzoic acid. CrystEngComm, 21 (13). pp. 2058-2066. ISSN 1466-8033

[img] Text (Ward-etal-CrystEngComm-2019-Discovery-and-recovery-of-delta-p-aminobenzoic-acid)
Ward_etal_CrystEngComm_2019_Discovery_and_recovery_of_delta_p_aminobenzoic_acid.pdf
Accepted Author Manuscript
Restricted to Repository staff only until 21 January 2020.
Download (1MB) | Request a copy from the Strathclyde author

    Abstract

    We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.

    Author(s):Ward, Martin R. ORCID logoORCID: https://orcid.org/0000-0003-0013-5004, Younis, Shatha, Cruz-Cabeza, Aurora J., Bull, Craig L., Funnell, Nicholas P. and Oswald, Iain D. H. ORCID logoORCID: https://orcid.org/0000-0003-4339-9392
    Item type:Article
    ID code:66798
    Keywords:p-aminobenzoic acid, neutron powder diffraction, high pressure, recovery, Chemistry, Chemistry(all), Pharmacology (medical)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:04 Feb 2019 12:54
    Last modified:06 Dec 2019 03:57
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/66798
    Export data:
    CORE (COnnecting REpositories)