Discovery and recovery of delta p-aminobenzoic acid

Ward, Martin R. and Younis, Shatha and Cruz-Cabeza, Aurora J. and Bull, Craig L. and Funnell, Nicholas P. and Oswald, Iain D. H. (2019) Discovery and recovery of delta p-aminobenzoic acid. CrystEngComm, 21 (13). pp. 2058-2066. ISSN 1466-8033

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    Abstract

    We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.

    ORCID iDs

    Ward, Martin R. ORCID logoORCID: https://orcid.org/0000-0003-0013-5004, Younis, Shatha, Cruz-Cabeza, Aurora J., Bull, Craig L., Funnell, Nicholas P. and Oswald, Iain D. H. ORCID logoORCID: https://orcid.org/0000-0003-4339-9392;
    • Item type:Article
      ID code:66798
      Dates:
      Date
      Event
      7 April 2019
      Published
      21 January 2019
      Published Online
      20 January 2019
      Accepted
      Keywords:p-aminobenzoic acid, neutron powder diffraction, high pressure, recovery, Chemistry, Chemistry(all), Pharmacology (medical)
      Subjects:Science > Chemistry
      Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
      Depositing user: Pure Administrator
      Date deposited:04 Feb 2019 12:54
      Last modified:11 Sep 2021 02:46
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/66798
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