P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection

Safar, Mohammed Adnan A and Cunningham, Margaret R; Wood, Rachel A and Kennedy, Charles, eds. (2018) P2Y1 and P2Y12 receptor heterodimerisation : from recombinant systems to native detection. In: Molecular Neuropharmacology in Health and Wellbeing, 2018-11-15 - 2018-11-15, University of Strathclyde Technology and Innovation Centre.

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    Abstract

    Purinergic P2Y1 and P2Y12 receptors belong to the class A family of transmembrane G protein-coupled receptors (GPCRs)1 and have been demonstrated to exist as homodimers, oligomers and form heterodimers with other GPCRs2. P2Y12 and protease-activated receptor 4 (PAR4) were recently reported to form a heterodimer with implications in receptor trafficking and signalling3. Our unpublished studies suggest that hP2Y1 and hP2Y12 heterodimerise therefore the aim of this study was to investigate the functional relevance of receptor interaction, firstly in recombinant systems and then natively in microglial cells.