High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions
Selin, Markus and Nummelin, Sami and Deleu, Jill and Ropponen, Jarmo and Viitala, Tapani and Lahtinen, Manu and Koivisto, Jari and Hirvonen, Jouni and Peltonen, Leena and Kostiainen, Mauri A and Bimbo, Luis M. (2018) High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions. Biomacromolecules, 19 (10). pp. 3983-3993. ISSN 1525-7797 (https://doi.org/10.1021/acs.biomac.8b00931)
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Abstract
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance the dissolution of poorly water-soluble drug compounds. The stabilizers exert their action through electrostatic or steric interactions, however, the molecular requirements of stabilizing agents have not been studied extensively. Here, four structurally related amphiphilic Janus-dendrimers were synthesized and screened to determine the roles of different macromolecular domains on the stabilization of drug crystals. Physical interaction and nanomilling experiments have substantiated that Janus-dendrimers with fourth generation hydrophilic dendrons were superior to third generation analogues and Poloxamer 188 in stabilizing indomethacin suspensions. Contact angle and surface plasmon resonance measurements support the hypothesis that Janus-dendrimers bind to indomethacin surfaces via hydrophobic interactions and that the number of hydrophobic alkyl tails determines the adsorption kinetics of the Janus-dendrimers. The results showed that amphiphilic Janus-dendrimers adsorb onto drug particles and thus can be used to provide steric stabilization against aggregation and recrystallization. The modular synthetic route for new amphiphilic Janus-dendrimers offers, thus, for the first time a versatile platform for stable general-use stabilizing agents of drug suspensions.
ORCID iDs
Selin, Markus, Nummelin, Sami, Deleu, Jill, Ropponen, Jarmo, Viitala, Tapani, Lahtinen, Manu, Koivisto, Jari, Hirvonen, Jouni, Peltonen, Leena, Kostiainen, Mauri A and Bimbo, Luis M. ORCID: https://orcid.org/0000-0002-8876-8297;-
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Item type: Article ID code: 65716 Dates: DateEvent8 October 2018Published28 August 2018Published Online27 August 2018AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 09 Oct 2018 10:39 Last modified: 26 Sep 2024 12:02 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/65716