Mapping the patent landscape of synthetic biology for fine chemical production pathways
Carbonell, Pablo and Gök, Abdullah and Shapira, Philip and Faulon, Jean-Loup (2016) Mapping the patent landscape of synthetic biology for fine chemical production pathways. Microbial Biotechnology, 9 (5). pp. 687-695. ISSN 1751-7915 (https://doi.org/10.1111/1751-7915.12401)
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Abstract
A goal of synthetic biology bio-foundries is to innovate through an iterative design/build/test/learn pipeline. In assessing the value of new chemical production routes, the intellectual property (IP) novelty of the pathway is important. Exploratory studies can be carried using knowledge of the patent/IP landscape for synthetic biology and metabolic engineering. In this paper, we perform an assessment of pathways as potential targets for chemical production across the full catalogue of reachable chemicals in the extended metabolic space of chassis organisms, as computed by the retrosynthesis-based algorithm RetroPath. Our database for reactions processed by sequences in heterologous pathways was screened against the PatSeq database, a comprehensive collection of more than 150M sequences present in patent grants and applications. We also examine related patent families using Derwent Innovations. This large-scale computational study provides useful insights into the IP landscape of synthetic biology for fine and specialty chemicals production.
ORCID iDs
Carbonell, Pablo, Gök, Abdullah ORCID: https://orcid.org/0000-0002-9378-3336, Shapira, Philip and Faulon, Jean-Loup;-
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Item type: Article ID code: 64489 Dates: DateEvent30 September 2016Published3 August 2016Published Online13 July 2016AcceptedNotes: The authors acknowledge funding from the BBSRC under grant BB/M017702/1, ‘Centre for Synthetic Biology of Fine and Speciality Chemicals’. JLF would like to acknowledge funding provided by the ANR grant ANR-15-CE1-0008. Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering Department: Strathclyde Business School > Hunter Centre for Entrepreneurship, Strategy and Innovation Depositing user: Pure Administrator Date deposited: 14 Jun 2018 15:33 Last modified: 07 Oct 2024 00:20 URI: https://strathprints.strath.ac.uk/id/eprint/64489