Picture of UK Houses of Parliament

Leading national thinking on politics, government & public policy through Open Access research

Strathprints makes available scholarly Open Access content by researchers in the School of Government & Public Policy, based within the Faculty of Humanities & Social Sciences.

Research here is 1st in Scotland for research intensity and spans a wide range of domains. The Department of Politics demonstrates expertise in understanding parties, elections and public opinion, with additional emphases on political economy, institutions and international relations. This international angle is reflected in the European Policies Research Centre (EPRC) which conducts comparative research on public policy. Meanwhile, the Centre for Energy Policy provides independent expertise on energy, working across multidisciplinary groups to shape policy for a low carbon economy.

Explore the Open Access research of the School of Government & Public Policy. Or explore all of Strathclyde's Open Access research...

Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index

Chakraborty, Mousumi and Ridgway, Cathy and Bawuah, Prince and Markl, Daniel and Gane, Patrick A.C. and Ketolainen, Jarkko and Zeitler, J. Axel and Peiponen, Kai Erik (2017) Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index. International Journal of Pharmaceutics, 525 (1). pp. 85-91. ISSN 0378-5173

[img]
Preview
Text (Chakraborty-etal-IJP-2017-Optics-based-compressibility-parameter-for-pharmaceutical-tablets-obtained)
Chakraborty_etal_IJP_2017_Optics_based_compressibility_parameter_for_pharmaceutical_tablets_obtained.pdf
Accepted Author Manuscript
License: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 logo

Download (815kB)| Preview

    Abstract

    The objective of this study is to propose a novel optical compressibility parameter for porous pharmaceutical tablets. This parameter is defined with the aid of the effective refractive index of a tablet that is obtained from non-destructive and contactless terahertz (THz) time-delay transmission measurement. The optical compressibility parameter of two training sets of pharmaceutical tablets with a priori known porosity and mass fraction of a drug was investigated. Both pharmaceutical sets were compressed with one of the most commonly used excipients, namely microcrystalline cellulose (MCC) and drug Indomethacin. The optical compressibility clearly correlates with the skeletal bulk modulus determined by mercury porosimetry and the recently proposed terahertz lumped structural parameter calculated from terahertz measurements. This lumped structural parameter can be used to analyse the pattern of arrangement of excipient and drug particles in porous pharmaceutical tablets. Therefore, we propose that the optical compressibility can serve as a quality parameter of a pharmaceutical tablet corresponding with the skeletal bulk modulus of the porous tablet, which is related to structural arrangement of the powder particles in the tablet.