Anti-RSV peptide-loaded liposomes for the inhibition of respiratory syncytial virus

Joshi, Sameer and Chaudhari, Atul A. and Dennis, Vida and Kirby, Daniel J. and Perrie, Yvonne and Singh, Shree Ram (2018) Anti-RSV peptide-loaded liposomes for the inhibition of respiratory syncytial virus. Bioengineering, 5 (2). 37. ISSN 2306-5354

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    Abstract

    Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.