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Paul McMenemy, Adam Kleczkowski, David N. Lees, James Lowther, Nick Taylor
A model for estimating pathogen variability in shellfish and predicting minimum depuration times
www.plosone.org
www.plosone.org
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(NoV)Tj
2.16 0 Td
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2.296 0 Td
(above)Tj
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2.058 0 Td
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4.0082 0 Td
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1.8595 0 Td
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1.389 0 Td
(consumption?)Tj
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5.913 0 Td
[()15(\r)]TJ
/F6 1 Tf
1.5704 0 Td
(Does)Tj
-34.8829 -1.2983 Td
(the)Tj
1.4626 0 Td
(model)Tj
2.7439 0 Td
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2.3868 0 Td
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5.1307 0 Td
(pathogens,)Tj
4.5297 0 Td
(such)Tj
2.0523 0 Td
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/F11 1 Tf
1.0148 0 Td
[()]TJ
0.9865 0 Td
[()7(\n)10()12()]TJ
/F6 1 Tf
(?)Tj
/F11 1 Tf
1.9275 0 Td
[(\r)]TJ
/F6 1 Tf
1.3039 0 Td
(Do)Tj
1.457 0 Td
(depuration)Tj
4.6432 0 Td
(times)Tj
2.381 0 Td
(mod-)Tj
-35.3874 -1.2983 Td
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2.0862 0 Td
(for)Tj
/F11 1 Tf
1.3833 0 Td
[()]TJ
0.9978 0 Td
[()7(\n)10()12()]TJ
/F6 1 Tf
1.5591 0 Td
(meet)Tj
2.1826 0 Td
(the)Tj
1.4684 0 Td
(minimum)Tj
4.2916 0 Td
(42)Tj
1.1735 0 Td
(hours)Tj
2.5115 0 Td
(depuration)Tj
4.6431 0 Td
(criterion?)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 338.4566 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Model)Tj
/F13 1 Tf
0 -1.5023 Td
(Pre-depuration)Tj
6.6472 0 Td
(pathogen)Tj
4.115 0 Td
(distribution)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 303.4771 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(We)Tj
1.61 0 Td
(begin)Tj
2.4265 0 Td
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1.1848 0 Td
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(density)Tj
3.1011 0 Td
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3.6283 0 Td
(\(p.d.f.\))Tj
2.914 0 Td
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1.3833 0 Td
(NoV)Tj
2.16 0 Td
(loads)Tj
2.296 0 Td
(within)Tj
2.812 0 Td
(a)Tj
0.6519 0 Td
(shellfish)Tj
-32.9723 -1.3039 Td
(population,)Tj
/F11 1 Tf
4.8131 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 254.4944 288.7937 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 260.2204 290.4377 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
/F11 1 Tf
0.7993 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 272.8629 288.7937 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 276.4346 290.4377 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(pre-depuration)Tj
6.3042 0 Td
(time)Tj
/F11 1 Tf
2.0296 0 Td
[()]TJ
/F6 1 Tf
0.5159 0 Td
(=)Tj
0.7994 0 Td
(0)Tj
0.6973 0 Td
(as)Tj
/F11 1 Tf
1.0148 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 432.2834 288.7937 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 435.8551 290.4377 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\).)Tj
0.7823 0 Td
(We)Tj
1.6101 0 Td
(assume)Tj
3.1464 0 Td
(that)Tj
1.7802 0 Td
(NoV)Tj
2.1543 0 Td
(loads)Tj
2.296 0 Td
(in)Tj
-35.3534 -1.2982 Td
(such)Tj
2.058 0 Td
(a)Tj
0.652 0 Td
(population)Tj
4.592 0 Td
(are)Tj
1.4514 0 Td
(well-approximated)Tj
7.7498 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.652 0 Td
(log-normal)Tj
4.7168 0 Td
(distribution,)Tj
5.1929 0 Td
(as)Tj
1.0148 0 Td
(many)Tj
2.4775 0 Td
(other)Tj
-31.7421 -1.2983 Td
(water-borne)Tj
5.1364 0 Td
(pathogens)Tj
4.303 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(previously)Tj
4.3483 0 Td
(shown)Tj
2.8516 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1451 0 Td
(well)Tj
1.8254 0 Td
(described)Tj
4.0479 0 Td
(by)Tj
1.1849 0 Td
(log-normal)Tj
-30.0527 -1.3209 Td
(behaviour)Tj
4.2406 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(37)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(].)Tj
3.2032 0 Td
(Thus)Tj
/F11 1 Tf
2.2507 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 327.8551 249.6188 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 331.37 251.2629 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5612 0 Td
(is)Tj
0.8504 0 Td
(described)Tj
4.0535 0 Td
(by)Tj
/F14 1 Tf
0 Tc
1.1792 0 Td
(LN)Tj
/F15 1 Tf
1.6781 0 Td
()Tj
/F16 1 Tf
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 423.9496 248.7685 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 427.4645 251.2629 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(;)Tj
/F16 1 Tf
0.4365 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 437.3858 254.8913 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.0677 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 440.844 251.2629 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
(,)Tj
0.8333 0 Td
(where)Tj
/F11 1 Tf
2.6476 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 480.7559 249.6188 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 486.4818 251.2629 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(is)Tj
0.8503 0 Td
(the)Tj
1.4684 0 Td
(mean)Tj
2.4491 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(log-)Tj
-35.8976 -1.3436 Td
(values)Tj
2.6646 0 Td
(of)Tj
1.0147 0 Td
(NoV)Tj
2.16 0 Td
(copies)Tj
2.7156 0 Td
(per)Tj
1.5364 0 Td
(gram)Tj
2.3074 0 Td
(\(cpg\))Tj
2.3074 0 Td
(per)Tj
1.5306 0 Td
(shellfish,)Tj
3.6964 0 Td
(and)Tj
/F11 1 Tf
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 421.285 236.1826 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 427.0677 237.8267 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(is)Tj
0.8447 0 Td
(the)Tj
1.4683 0 Td
(standard)Tj
3.7247 0 Td
(deviation)Tj
3.9458 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(log-)Tj
-35.1776 -1.2982 Td
(values)Tj
2.6645 0 Td
(of)Tj
1.0148 0 Td
(NoV)Tj
2.16 0 Td
(cpg)Tj
1.6271 0 Td
(per)Tj
1.5307 0 Td
(shellfish.)Tj
3.6907 0 Td
(It)Tj
0.8617 0 Td
(follows)Tj
3.0557 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
1.4683 0 Td
(arithmetic)Tj
4.3539 0 Td
(mean)Tj
2.4435 0 Td
(\(or)Tj
1.4399 0 Td
(expected)Tj
3.7247 0 Td
(value\))Tj
-31.8157 -1.3096 Td
(and)Tj
1.7291 0 Td
(standard)Tj
3.7247 0 Td
(deviation)Tj
3.9458 0 Td
(of)Tj
/F11 1 Tf
1.0148 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 317.707 210.0472 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 321.2787 211.748 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5555 0 Td
(are)Tj
1.4514 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
/F12 1 Tf
0 Tc
1.0318 0.017 Td
()Tj
/F11 1 Tf
-0.017 -0.017 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 389.1401 209.2535 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 395.433 211.748 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 420.2078 209.2535 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 423.6661 211.748 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6633 0 Td
()Tj
/F18 1 Tf
1.0488 0 Td
[()2()]TJ
/F15 1 Tf
(f)Tj
/F16 1 Tf
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 465.2787 209.2535 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 471.0047 211.748 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F16 1 Tf
0.9977 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 486.4818 215.3763 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.0677 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 489.9968 211.748 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(=)Tj
/F12 1 Tf
(2)Tj
/F15 1 Tf
(g)Tj
/F6 1 Tf
-0.004 Tc
1.7177 0 Td
(and)Tj
/F11 1 Tf
0 Tc
-30.7159 -1.508 Td
[()8()]TJ
/F15 1 Tf
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 220.0818 194.1732 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 223.5968 196.6677 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6576 0 Td
()Tj
/F19 1 Tf
2.0523 0.8333 Td
()Tj
4.8075 0 Td
()Tj
/F18 1 Tf
-4.8075 -0.8333 Td
[()2()]TJ
/F15 1 Tf
(f)Tj
/F16 1 Tf
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 275.1874 199.559 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -0.9449 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 278.7023 196.6677 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(g)Tj
0.7256 0 Td
( )Tj
/F12 1 Tf
0.9921 0 Td
(1)Tj
/F19 1 Tf
-5.5217 0.8333 Td
(p)Tj
/F18 1 Tf
6.1907 -0.8333 Td
[()2()]TJ
0.8731 0 Td
[()]TJ
/F15 1 Tf
(f)Tj
/F16 1 Tf
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 327.0614 194.1732 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 332.7874 196.6677 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F16 1 Tf
0.9921 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 348.2645 200.296 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.0677 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 351.7795 196.6677 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(=)Tj
/F12 1 Tf
(2)Tj
/F15 1 Tf
(g)Tj
/F6 1 Tf
-0.004 Tc
1.7177 0 Td
(respectively.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F13 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Depuration)Tj
5.0787 0 Td
(pathogen)Tj
4.115 0 Td
(distribution)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 148.0251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(A)Tj
0.9014 0 Td
(probability)Tj
4.5977 0 Td
(distribution,)Tj
/F11 1 Tf
5.1931 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 320.485 146.3244 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 322.696 148.0251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\),)Tj
0.788 0 Td
(that)Tj
1.7801 0 Td
(describes)Tj
3.8835 0 Td
(the)Tj
1.4683 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0148 0 Td
(NoV)Tj
2.16 0 Td
(during)Tj
2.9253 0 Td
(depuration)Tj
4.6431 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 567.0425 146.3244 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 569.3102 148.0251 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
-36.9295 -1.3039 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1509 0 Td
(derived)Tj
3.2144 0 Td
(by)Tj
1.1792 0 Td
(assuming)Tj
4.0025 0 Td
(that)Tj
/F11 1 Tf
1.7802 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 334.2047 133.3417 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 339.9874 134.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(is)Tj
0.8447 0 Td
(related)Tj
2.948 0 Td
(to)Tj
/F11 1 Tf
1.0261 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 392.8251 133.3417 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 397.2472 134.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(by)Tj
1.1792 0 Td
(some)Tj
2.33 0 Td
(continuous)Tj
4.7395 0 Td
(function)Tj
/F11 1 Tf
3.6283 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 520.6677 133.3417 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 525.0897 134.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
/F11 1 Tf
0.7993 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 543.7984 133.3417 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 547.37 134.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(;)Tj
/F11 1 Tf
0.4478 0 Td
[()]TJ
/F6 1 Tf
(\).)Tj
-35.1833 -1.2982 Td
(Previous)Tj
3.6907 0 Td
(studies,)Tj
3.2088 0 Td
(such)Tj
2.0636 0 Td
(as)Tj
1.0148 0 Td
(those)Tj
2.3357 0 Td
(by)Tj
1.1792 0 Td
(Polo)Tj
/F11 1 Tf
2.041 0 Td
[()8()]TJ
0.9127 0 Td
[()11()]TJ
/F6 1 Tf
0.9411 0 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(42)Tj
0 g
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[()12()]TJ
/F6 1 Tf
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 597.3165 cm
BT
/F13 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Tail)Tj
1.8897 0 Td
(of)Tj
1.0678 0 Td
(the)Tj
1.5448 0 Td
(distribution)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
10 0 0 10 200.0125 580.3086 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Eq)Tj
1.2925 0 Td
(1)Tj
0 g
0.6974 0 Td
(describes)Tj
3.8834 0 Td
(a)Tj
0.6576 0 Td
(positively)Tj
4.0139 0 Td
(skewed)Tj
3.1407 0 Td
(p.d.f.)Tj
2.2281 0 Td
(where)Tj
2.6475 0 Td
(the)Tj
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1.4683 0 Td
[()11()16()4()]TJ
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1.5081 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4741 0 Td
(p.d.f.)Tj
2.228 0 Td
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(defined)Tj
3.2258 0 Td
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1.0148 0 Td
(including)Tj
4.0422 0 Td
(val-)Tj
-35.3818 -1.2982 Td
(ues)Tj
1.5306 0 Td
(of)Tj
/F11 1 Tf
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 230.1165 565.6251 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 234.5385 567.3259 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(greater)Tj
3.0103 0 Td
(than)Tj
/F20 1 Tf
2.0239 0 Td
(C)Tj
/F6 1 Tf
(,)Tj
1.27 0 Td
(a)Tj
0.6519 0 Td
(measure)Tj
3.583 0 Td
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1.0148 0 Td
(food)Tj
2.0521 0 Td
(safety)Tj
2.4775 0 Td
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0.8504 0 Td
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3.8154 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(consumer)Tj
4.2009 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(S1)Tj
1.1679 0 Td
(Fig)Tj
0 g
(\).)Tj
2.0466 0 Td
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1.7858 0 Td
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2.8119 0 Td
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(of)Tj
1.0148 0 Td
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(p.d.)Tj
-35.8012 -1.3039 Td
(f.,)Tj
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0.9581 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 223.1433 539.6598 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 227.5653 541.3039 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(>)Tj
/F20 1 Tf
-0.004 Tc
0.9921 0 Td
(C)Tj
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1.6044 0 Td
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1.0148 0 Td
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4.1159 0 Td
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1.0148 0 Td
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4.5297 0 Td
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4.1896 0 Td
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1.2643 0 Td
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1.2018 0 Td
(time)Tj
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2.0296 0 Td
[()]TJ
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0.7427 0 Td
(the)Tj
1.474 0 Td
(probability)Tj
4.5921 0 Td
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3.464 0 Td
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2.9196 0 Td
(a)Tj
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1.0374 0 Td
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(given)Tj
2.3811 0 Td
(by)Tj
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0 Tc
-25.6534 -3.0217 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 255.5149 482.6267 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 260.844 485.1212 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(>)Tj
/F20 1 Tf
1.0488 0 Td
(C)Tj
/F15 1 Tf
()Tj
1.4853 0 Td
()Tj
/F19 1 Tf
1.0488 1.3549 Td
(Z)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 301.2094 500.7118 cm
BT
/F15 1 Tf
1 TL
0 0 Td
(1)Tj
/F20 1 Tf
-0.7086 -5.0269 Td
(C)Tj
ET
Q
q
1 j
1 J
0 w
308.863 487.8425 m
347.2441 487.8425 l
347.2441 487.389 l
308.863 487.389 l
f*
10 0 0 10 325.5307 491.9244 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(1)Tj
/F19 1 Tf
-0.8447 -0.6519 Td
()Tj
0.8447 0 Td
()Tj
/F12 1 Tf
-0.8447 -0.8391 Td
(2)Tj
/F16 1 Tf
(p)Tj
/F15 1 Tf
-0.822 0.8391 Td
(p)Tj
/F16 1 Tf
1.8764 -0.8391 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 333.1842 474.5196 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 339.9874 477.0141 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 344.6929 474.5196 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 348.8881 485.1212 cm
BT
/F18 1 Tf
1 TL
0 0 Td
[()2()]TJ
ET
Q
q
1 j
1 J
0 w
372.0756 487.8425 m
455.3575 487.8425 l
455.3575 487.389 l
372.0756 487.389 l
f*
10 0 0 10 372.0755 491.9244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
0.771 0 Td
()Tj
/F18 1 Tf
[()1()]TJ
/F15 1 Tf
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 400.0818 489.4299 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 402.633 491.9244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
/F11 1 Tf
0.9978 0 Td
[()12()]TJ
/F15 1 Tf
1.0375 0 Td
( )Tj
/F16 1 Tf
0.9977 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 444.4724 489.4299 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 447.9874 491.9244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 451.8425 497.0834 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 406.7149 478.2614 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
/F16 1 Tf
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 417.2031 481.8897 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.0677 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 364.5354 499.2377 cm
BT
/F19 1 Tf
1 TL
0 0 Td
()Tj
9.0821 0 Td
()Tj
/F11 1 Tf
1.4116 -1.4116 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 479.1685 482.6267 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 484.4976 485.1212 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F12 1 Tf
1.0488 0 Td
(1)Tj
/F15 1 Tf
0.72 0 Td
( )Tj
/F11 1 Tf
0.9977 0 Td
[()]TJ
/F17 1 Tf
0.737 0 Td
(:)Tj
/F15 1 Tf
4.3937 -0.068 Td
()Tj
/F6 1 Tf
(2)Tj
/F15 1 Tf
()Tj
/F6 1 Tf
-0.004 Tc
-36.3455 -3.3902 Td
(Mathematically,)Tj
6.6444 0 Td
(some)Tj
2.3301 0 Td
(remnant)Tj
3.6623 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(tail)Tj
1.4627 0 Td
(will)Tj
1.6667 0 Td
(never)Tj
2.4378 0 Td
(fall)Tj
1.4343 0 Td
(below)Tj
2.5909 0 Td
(the)Tj
1.4683 0 Td
(value)Tj
2.3073 0 Td
(of)Tj
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1.0148 0 Td
(C)Tj
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1.2642 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(value)Tj
2.3074 0 Td
(of)Tj
/F11 1 Tf
1.0148 0 Td
[()]TJ
/F6 1 Tf
-36.578 -1.2983 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 208.0629 435.8551 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 212.485 437.5559 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(>)Tj
/F20 1 Tf
-0.004 Tc
0.9921 0 Td
(C)Tj
/F6 1 Tf
(\))Tj
1.3776 0 Td
(will)Tj
1.6668 0 Td
(decay)Tj
2.4831 0 Td
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1.0261 0 Td
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1.9332 0 Td
(only)Tj
1.9729 0 Td
(as)Tj
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1.0148 0 Td
[()]TJ
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0 Tc
0.6067 0 Td
(!)Tj
1.3039 0 Td
(1)Tj
/F6 1 Tf
-0.004 Tc
(.)Tj
1.4456 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4684 0 Td
(log-normal)Tj
4.7168 0 Td
(distribution)Tj
4.9662 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Eq)Tj
1.2926 0 Td
(1)Tj
0 g
(,)Tj
0.9241 0 Td
(there)Tj
2.262 0 Td
(is)Tj
-35.3647 -1.3039 Td
(always)Tj
2.8345 0 Td
(a)Tj
0.652 0 Td
(non-zero)Tj
3.8891 0 Td
(probability)Tj
/F11 1 Tf
4.5978 0 Td
[()]TJ
/F6 1 Tf
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 333.2976 422.8724 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 335.5086 424.5165 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
/F17 1 Tf
0 Tc
0.5612 0 Td
(>)Tj
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-0.004 Tc
0.9921 0 Td
(C)Tj
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(,)Tj
1.2643 0 Td
(i.e.)Tj
1.3606 0 Td
(there)Tj
2.262 0 Td
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0.8504 0 Td
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2.8346 0 Td
(a)Tj
0.652 0 Td
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4.5978 0 Td
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1.7801 0 Td
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1.4684 0 Td
(NoV)Tj
2.1599 0 Td
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1.9333 0 Td
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-36.2662 -1.2982 Td
(an)Tj
1.2019 0 Td
(randomly)Tj
4.1272 0 Td
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3.3506 0 Td
(shellfish)Tj
3.4639 0 Td
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1.9331 0 Td
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2.9026 0 Td
(the)Tj
1.4741 0 Td
(threshold)Tj
4.0081 0 Td
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2.0126 0 Td
(C)Tj
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(.)Tj
1.2642 0 Td
(Public)Tj
2.7553 0 Td
(health)Tj
2.6759 0 Td
(authorities)Tj
-31.1695 -1.2983 Td
(would)Tj
2.7099 0 Td
(require)Tj
3.1125 0 Td
(that)Tj
1.7801 0 Td
(this)Tj
1.6724 0 Td
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4.5977 0 Td
(value)Tj
2.3074 0 Td
(be)Tj
1.1508 0 Td
(very)Tj
1.9219 0 Td
(small.)Tj
2.5512 0 Td
(Therefore)Tj
4.1669 0 Td
(we)Tj
1.3266 0 Td
(define)Tj
2.6986 0 Td
(an)Tj
1.2075 0 Td
(additional)Tj
4.2746 0 Td
(vari-)Tj
-35.4781 -1.3039 Td
(able)Tj
1.8312 0 Td
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1.0318 0 Td
(the)Tj
1.474 0 Td
(model)Tj
2.7439 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
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1.2019 0 Td
[()10()10()12( )20()16()6()7()]TJ
4.0308 0 Td
[()4()-5(\r)3()15()]TJ
/F6 1 Tf
(,)Tj
/F11 1 Tf
2.1316 0 Td
[()]TJ
/F6 1 Tf
(,)Tj
1.0148 0 Td
(which)Tj
2.6532 0 Td
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0.8504 0 Td
(the)Tj
1.4683 0 Td
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4.5978 0 Td
(that)Tj
1.7745 0 Td
(a)Tj
0.6576 0 Td
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4.1272 0 Td
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-32.6038 -1.2983 Td
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3.4696 0 Td
(at)Tj
0.9524 0 Td
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2.024 0 Td
[()]TJ
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0.5215 0 Td
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1.6611 0 Td
(have)Tj
2.0636 0 Td
(a)Tj
0.652 0 Td
(NoV)Tj
2.16 0 Td
(load)Tj
1.9331 0 Td
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2.5852 0 Td
(the)Tj
1.4683 0 Td
(threshold)Tj
4.0139 0 Td
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2.5285 0 Td
(C)Tj
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(.)Tj
1.2699 0 Td
(Thus)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(tail)Tj
1.4684 0 Td
(of)Tj
0.83 0.64 0.02 0 k
1.0148 0 Td
(Eq)Tj
1.2926 0 Td
(2)Tj
0 g
0.6973 0 Td
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-35.4895 -1.2982 Td
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1.7688 0 Td
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4.3087 0 Td
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1.1792 0 Td
(1)Tj
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0.6973 0 Td
[()]TJ
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0.788 0 Td
[()]TJ
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(,)Tj
1.0148 0 Td
(and)Tj
1.7291 0 Td
(so)Tj
1.0885 0 Td
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1.0261 0 Td
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3.9911 0 Td
(any)Tj
1.6611 0 Td
(food)Tj
2.0466 0 Td
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2.4832 0 Td
(implications,)Tj
5.3971 0 Td
(the)Tj
1.474 0 Td
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2.3017 0 Td
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[()]TJ
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0 Tc
0.788 0 Td
()Tj
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-0.004 Tc
0.9921 0 Td
(1.)Tj
-35.7559 -1.2983 Td
(Both)Tj
2.1317 0 Td
(of)Tj
1.0148 0 Td
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2.2563 0 Td
(values,)Tj
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2.8914 0 Td
(C)Tj
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1.0374 0 Td
(and)Tj
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1.7291 0 Td
[()]TJ
/F6 1 Tf
(,)Tj
1.0148 0 Td
(could)Tj
2.4547 0 Td
(be)Tj
1.1509 0 Td
(defined)Tj
3.2258 0 Td
(by)Tj
1.1792 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(authorities)Tj
4.5071 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.0749 0 Td
(All)Tj
1.3946 0 Td
(parame-)Tj
-33.4485 -1.3039 Td
(ters)Tj
1.6725 0 Td
(used)Tj
2.0579 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Eq)Tj
1.2982 0 Td
(2)Tj
0 g
0.6917 0 Td
(are)Tj
1.4513 0 Td
(defined)Tj
3.2258 0 Td
(and)Tj
1.7291 0 Td
(described)Tj
4.0535 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(Table)Tj
2.4378 0 Td
(1)Tj
0 g
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 306.8787 cm
BT
/F13 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Minimum)Tj
4.4646 0 Td
(depuration)Tj
4.8661 0 Td
(time)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 289.8708 cm
BT
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(0)Tj
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1 J
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[()]TJ
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(1)Tj
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10 0 0 10 467.6031 597.1464 cm
BT
/F12 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
-0.0226 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 472.7622 594.5385 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 467.7165 583.37 cm
BT
/F20 1 Tf
1 TL
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(C)Tj
/F19 1 Tf
-0.7653 2.0919 Td
()Tj
1.6213 0 Td
()Tj
-15.6414 0 Td
()Tj
16.3727 0 Td
()Tj
/F17 1 Tf
0.686 -1.406 Td
(:)Tj
/F15 1 Tf
7.302 0 Td
()Tj
/F6 1 Tf
(4)Tj
/F15 1 Tf
()Tj
0.83 0.64 0.02 0 k
/F6 1 Tf
-0.004 Tc
-36.3455 -2.8402 Td
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1.2926 0 Td
(4)Tj
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1.0261 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 400.5354 560.1259 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 404.107 561.8267 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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0 Tc
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ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 339.5905 539.0929 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 345.8834 541.5874 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F19 1 Tf
1.8708 0.839 Td
()Tj
0.2948 0 Td
()Tj
/F12 1 Tf
-0.2948 -0.839 Td
(2)Tj
/F15 1 Tf
-0.822 0.839 Td
(p)Tj
/F18 1 Tf
1.3209 -0.839 Td
[()1()-4()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 381.3165 546.3496 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F12 1 Tf
0.7653 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 389.4236 541.5874 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F12 1 Tf
(2)Tj
/F11 1 Tf
[()]TJ
/F15 1 Tf
1.6837 0 Td
( )Tj
/F12 1 Tf
0.9921 0 Td
(1)Tj
/F15 1 Tf
()Tj
/F17 1 Tf
1.0545 0 Td
(;)Tj
/F15 1 Tf
13.6743 0.0793 Td
()Tj
/F6 1 Tf
(5)Tj
/F15 1 Tf
()Tj
/F6 1 Tf
-0.004 Tc
-35.1493 -2.3413 Td
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2.2507 0 Td
(the)Tj
1.4683 0 Td
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3.719 0 Td
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1.0148 0 Td
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1.4684 0 Td
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4.1045 0 Td
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2.0183 0 Td
[()]TJ
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0.788 0 Td
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1.7687 0 Td
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4.4277 0 Td
(the)Tj
1.4683 0 Td
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4.3767 0 Td
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2.3017 0 Td
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/F11 1 Tf
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 538.5259 517.3228 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 544.3086 518.9669 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(at)Tj
0.9524 0 Td
(a)Tj
-35.3817 -1.2982 Td
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2.6645 0 Td
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1.8652 0 Td
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3.7701 0 Td
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1.0262 0 Td
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4.2916 0 Td
(depuration)Tj
4.6431 0 Td
(time.)Tj
2.2507 0 Td
(This)Tj
1.9899 0 Td
(worst)Tj
2.4378 0 Td
(case)Tj
1.8652 0 Td
(variabil-)Tj
-33.8511 -1.2983 Td
(ity)Tj
1.2415 0 Td
(\(WCV\))Tj
3.2202 0 Td
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0.8504 0 Td
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0.6519 0 Td
(consequence)Tj
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(truncated)Tj
4.0706 0 Td
(at)Tj
/F11 1 Tf
0.9524 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 542.6078 491.3007 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 547.0866 493.0015 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(=)Tj
0.7993 0 Td
(0)Tj
0.6917 0 Td
(yet)Tj
-36.1981 -1.3039 Td
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1.542 0 Td
(no)Tj
1.2756 0 Td
(upper)Tj
2.5738 0 Td
(limit.)Tj
2.3471 0 Td
(As)Tj
1.2642 0 Td
(variability)Tj
4.2236 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 340.3275 478.3181 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 343.8425 479.9622 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(\))Tj
0.5612 0 Td
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0.8504 0 Td
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4.2236 0 Td
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2.4548 0 Td
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/F11 1 Tf
1.0148 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 312.548 465.3354 cm
BT
/F11 1 Tf
1 TL
-0.0053 Tc
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 314.8157 466.9795 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
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(,)Tj
0.4422 0 Td
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2.3697 0 Td
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1.6894 0 Td
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1.7802 0 Td
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2.5455 0 Td
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1.4683 0 Td
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(\()Tj
/F11 1 Tf
[()]TJ
/F6 1 Tf
(\))Tj
1.4683 0 Td
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-34.8998 -1.3039 Td
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0.8447 0 Td
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3.6397 0 Td
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1.0261 0 Td
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1.4343 0 Td
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2.5909 0 Td
(the)Tj
1.4683 0 Td
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2.1542 0 Td
(threshold)Tj
4.0139 0 Td
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2.5285 0 Td
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1.2642 0 Td
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1.9899 0 Td
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3.1861 0 Td
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0.8448 0 Td
(fully)Tj
1.9842 0 Td
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4.0535 0 Td
(by)Tj
0.83 0.64 0.02 0 k
1.1792 0 Td
(Eq)Tj
1.2983 0 Td
(4)Tj
0 g
(,)Tj
-35.5008 -1.2983 Td
(but)Tj
1.5534 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1451 0 Td
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4.0252 0 Td
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1.0318 0 Td
(terms)Tj
2.4944 0 Td
(excluding)Tj
/F11 1 Tf
4.1159 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 364.5921 426.3307 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 370.3748 427.9748 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(by)Tj
1.1792 0 Td
(substituting)Tj
4.9492 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0318 0 Td
(Eq)Tj
1.2983 0 Td
(5)Tj
0 g
(:)Tj
/F11 1 Tf
0 Tc
-15.8115 -2.5398 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 302.7968 400.0818 cm
BT
/F18 1 Tf
1 TL
0 0 Td
[( )35(\n)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 319.9181 402.5763 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
1.0488 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 335.2251 406.2047 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F12 1 Tf
0.7653 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 348.548 402.5763 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F18 1 Tf
[()1()-4()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 364.0818 407.3385 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F12 1 Tf
0.7748 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 372.2456 402.5763 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F12 1 Tf
(2)Tj
/F11 1 Tf
[()]TJ
/F15 1 Tf
1.678 0 Td
( )Tj
/F12 1 Tf
0.9978 0 Td
(1)Tj
/F15 1 Tf
()Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 411.7039 407.7354 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 417.4299 402.5763 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F18 1 Tf
0.9921 0 Td
[()1()]TJ
ET
Q
q
1 j
1 J
0 w
442.5449 405.2409 m
451.4457 405.2409 l
451.4457 404.8441 l
442.5449 404.8441 l
f*
10 0 0 10 442.7149 409.5496 cm
BT
/F12 1 Tf
1 TL
0 0 Td
()Tj
/F11 1 Tf
-0.017 -0.017 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 447.9307 406.885 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 442.885 395.7165 cm
BT
/F20 1 Tf
1 TL
0 0 Td
(C)Tj
/F19 1 Tf
-0.7653 2.0976 Td
()Tj
1.6213 0 Td
()Tj
-10.8112 0 Td
()Tj
11.5425 0 Td
()Tj
/F17 1 Tf
0.5216 -1.4117 Td
(;)Tj
/F15 1 Tf
9.9496 0 Td
()Tj
/F6 1 Tf
(6)Tj
/F15 1 Tf
()Tj
/F6 1 Tf
-0.004 Tc
-36.3455 -2.8402 Td
(where)Tj
/F11 1 Tf
2.6475 0 Td
[( )]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 232.3842 372.4724 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(WCV)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 252 374.1732 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(is)Tj
0.8503 0 Td
(the)Tj
1.4684 0 Td
(minimum)Tj
4.2859 0 Td
(depuration)Tj
4.6432 0 Td
(time)Tj
2.0295 0 Td
(required)Tj
3.6397 0 Td
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1.0261 0 Td
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2.6816 0 Td
(the)Tj
1.474 0 Td
(constraints)Tj
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(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(param-)Tj
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(eters)Tj
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2.0977 0 Td
[()]TJ
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0.788 0 Td
(and)Tj
/F20 1 Tf
1.7291 0 Td
(C)Tj
/F6 1 Tf
(,)Tj
1.2642 0 Td
(while)Tj
2.3697 0 Td
(assuming)Tj
4.0025 0 Td
(a)Tj
0.6576 0 Td
(WCV)Tj
2.5399 0 Td
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1.0148 0 Td
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1.474 0 Td
(pathogen)Tj
3.9401 0 Td
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2.6759 0 Td
(the)Tj
1.4683 0 Td
(shellfish)Tj
3.4696 0 Td
(population.)Tj
-28.2951 -1.2982 Td
(Assuming)Tj
4.2575 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(parameters)Tj
4.6715 0 Td
(which)Tj
2.6532 0 Td
(control)Tj
3.1181 0 Td
(the)Tj
1.474 0 Td
(food)Tj
2.0466 0 Td
(safety)Tj
2.4775 0 Td
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1.0148 0 Td
(our)Tj
1.6214 0 Td
(model)Tj
2.7439 0 Td
(\()Tj
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[()]TJ
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-35.1663 -1.2983 Td
(and)Tj
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1.7292 0 Td
(C)Tj
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(\))Tj
1.3776 0 Td
(would)Tj
2.7155 0 Td
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1.1508 0 Td
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2.1884 0 Td
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1.1848 0 Td
(legislation)Tj
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1.0375 0 Td
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(future,)Tj
2.8857 0 Td
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1.9729 0 Td
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1.474 0 Td
(depuration)Tj
4.6375 0 Td
(efficacy)Tj
3.2258 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(pro-)Tj
-35.8296 -1.3039 Td
(cess)Tj
1.7859 0 Td
(being)Tj
2.4321 0 Td
(used)Tj
2.0635 0 Td
(\()Tj
/F11 1 Tf
[()]TJ
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(\))Tj
1.3719 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.474 0 Td
(estimate)Tj
3.5433 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(average)Tj
3.2258 0 Td
(NoV)Tj
2.16 0 Td
(load)Tj
1.9332 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(shellfish)Tj
3.4696 0 Td
(population)Tj
4.5864 0 Td
(\()Tj
/F12 1 Tf
0 Tc
0.3628 0.017 Td
()Tj
/F11 1 Tf
-0.0226 -0.017 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 559.9559 319.6346 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 563.4708 322.1291 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
-36.3455 -1.3095 Td
(are)Tj
1.4456 0 Td
(required)Tj
3.6397 0 Td
(to)Tj
1.0261 0 Td
(calculate)Tj
3.6794 0 Td
(MDTs.)Tj
-8.5946 -1.3153 Td
(The)Tj
1.7858 0 Td
(expected)Tj
3.719 0 Td
(value)Tj
2.3074 0 Td
(of)Tj
0.83 0.64 0.02 0 k
1.0148 0 Td
(Eq)Tj
1.2983 0 Td
(1)Tj
0 g
0.6973 0 Td
(was)Tj
1.6951 0 Td
(previously)Tj
4.354 0 Td
(defined)Tj
3.2258 0 Td
(as)Tj
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0 Tc
1.0148 0 Td
[()]TJ
/F15 1 Tf
0.5726 0 Td
()Tj
/F11 1 Tf
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 437.3858 293.3858 cm
BT
/F11 1 Tf
1 TL
0 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 439.937 295.8803 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6576 0 Td
()Tj
/F18 1 Tf
1.0488 0 Td
[()2()]TJ
/F15 1 Tf
(f)Tj
/F16 1 Tf
(m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 481.5496 293.3858 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 487.2755 295.8803 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F11 1 Tf
0.9921 0 Td
[()12()]TJ
/F15 1 Tf
1.0431 0 Td
()Tj
/F16 1 Tf
0.9921 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 523.0488 299.5086 cm
BT
/F12 1 Tf
1 TL
0 0 Td
(2)Tj
0 -1.0677 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
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