Ocular toxoplasmosis : clinical features, pathology, pathogenesis, animal models and immune responses

Roberts, Fiona and Kuo, Annie and Jones, Leigh and McLeod, Rima and Roberts, Craig (2007) Ocular toxoplasmosis : clinical features, pathology, pathogenesis, animal models and immune responses. In: Toxoplasma. Horizon Scientific Press, Norfolk, pp. 59-91. ISBN 9781904933342

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Abstract

Ocular toxoplasmosis occurs during the acute acquired infection, during active congenital infection in utero and the newborn period and as a recudescent sequela of both types of infection. It also occurs in immune compromised persons usually as reactivation disease. Destruction of the eye is secondary to parasite replication and the immune response to parasite growth may augment this destruction. Clinical features, parthogenesis, immunology and protective and pathogenic mechanisms, pathology, animal models for study of the disease, and methods of treatment are summerized and discussed.