Genomics of lithium action and response

Pickard, Benjamin S. (2017) Genomics of lithium action and response. Neurotherapeutics, 14 (3). pp. 582-587. ISSN 1878-7479

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    Abstract

    Lithium is the most successful mood stabiliser treatment for bipolar disorder. However, unlike conventional drugs that are designed to interact with a specific molecular target, the actions of lithium are distributed across many biological processes and pathways. Treatment response is subject to genetic variation between individuals and similar genetic variation may dictate susceptibility to side-effects. Transcriptomic, genomic and cell model research strategies have all been deployed in the search for the genetic factors and biological systems that mediate the interaction between genetics and the therapeutic actions of lithium. In this review, recent findings from genome-wide studies and patient cell lines will be summarised and discussed from a standpoint that genuine progress is being made to define clinically useful mechanisms of this treatment, to place it in the context of bipolar disorder pathology, and to move towards a time when the prescription of lithium is targeted to those individuals who will derive the greatest benefit.

    Author(s):Pickard, Benjamin S. ORCID logoORCID: https://orcid.org/0000-0002-2374-6329
    Item type:Article
    ID code:60868
    Keywords:lithium, mood stabilsers, bipolar disorder, genetic factors, therapeutic actions, patient cell lines, Pharmacy and materia medica, Pharmaceutical Science
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:08 Jun 2017 09:46
    Last modified:17 Feb 2020 04:54
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/60868
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