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Discover open research at Strathprints as part of International Open Access Week!

23-29 October 2017 is International Open Access Week. The Strathprints institutional repository is a digital archive of Open Access research outputs, all produced by University of Strathclyde researchers.

Explore recent world leading Open Access research content this Open Access Week from across Strathclyde's many research active faculties: Engineering, Science, Humanities, Arts & Social Sciences and Strathclyde Business School.

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Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons

Robertson, G. and Sposito, T. and Wray, S. and Hardy, J. and Bushell, T.J. and Zagnoni, M. (2016) Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, California, pp. 379-380. ISBN 9781510834163

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Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.