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On-chip formation of 3D spheroids for patient-derived tissue screening

Christ, T. and Payne, S. and Yan, Y. and Ren, J. and Edwards, J. and Boyd, M. and Zagnoni, M. (2016) On-chip formation of 3D spheroids for patient-derived tissue screening. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Chemical and Biological Microsystems Society, San Diego, CA, pp. 577-578. ISBN 9781510834163

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Abstract

Three-dimensional (3D) multicellular spheroids have been identified as a suitable model of solid tumours for drug screening and cancer research [1]. However, creating and monitoring a large number of spheroids using conventional methods remains labour-intensive. This work reports a novel double-layer microfluidic device for the generation and culture of 3D multicellular spheroids and its use with biopsy samples. The system enables drug concentration-response curves to be obtained from a limited amount of sample material by applying a drug concentration gradient using an integrated passive microchannel network.