Picture map of Europe with pins indicating European capital cities

Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Strathprints

Constructing tissue-like complex structures using cell-laden DNA hydrogel bricks

Wang, Yijie and Shao, Yu and Ma, Xiaozhou and Zhou, Bini and Faulkner-Jones, Alan and Shu, Wenmiao and Liu, Dongsheng (2017) Constructing tissue-like complex structures using cell-laden DNA hydrogel bricks. ACS Applied Materials and Interfaces, 9 (14). pp. 12311-12315. ISSN 1944-8244

[img]
Preview
 Text (Wang-etal-AMI2017-Constructing-tissue-like-complex-structures-using-cell-laden)
Wang_etal_AMI2017_Constructing_tissue_like_complex_structures_using_cell_laden.pdf - Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (5MB) | Preview

Abstract

Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new "brick-to-wall" based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.

Item type: Article
ID code: 60259
Keywords: DNA hydrogel, tissue engineering, cell arrangements, cell migration, self-healing, supramolecular, Bioengineering, Biomedical Engineering
Subjects: Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department: Faculty of Engineering > Biomedical Engineering
Depositing user: Pure Administrator
Date deposited: 23 Mar 2017 10:13
Last modified: 21 Sep 2017 14:06
Related URLs:
URI: https://strathprints.strath.ac.uk/id/eprint/60259
Export data:
CORE (COnnecting REpositories)