Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345
Cheng, Cheng and Othman, Eman M. and Fekete, Agnes and Krischke, Markus and Stopper, Helga and Edrada-Ebel, Ru Angelie and Mueller, Martin J. and Hentschel, Ute and Abdelmohsen, Usama Ramadan (2016) Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345. Tetrahedron Letters, 57 (37). pp. 4196-4199. ISSN 0040-4039 (https://doi.org/10.1016/j.tetlet.2016.08.005)
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Abstract
One new phenoxazin analogue, strepoxazine A (1), along with two known antibiotic phenazines phencomycin (2) and tubermycin B (3) were isolated from the solid culture of Streptomyces sp. SBT345 which had previously been recovered from the Mediterranean sponge Agelas oroides. The structures of compounds 1, 2 and 3 were determined by spectroscopic analyses including 1D and 2D NMR, and HR-ESI-MS experiments as well as comparison to the literature. We further investigated the apoptotic effect of the three compounds on the human promyelocytic leukaemia cells HL-60 and human breast adenocarcinoma cells MCF-7. Only strepoxazine A (1) showed cytotoxicity against leukaemia cells HL-60 cells. These results demonstrate that sponge-associated actinomycetes are rich sources for natural products with new pharmacological activities and relevance to drug discovery.
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Item type: Article ID code: 59868 Dates: DateEvent14 September 2016Published3 August 2016Published Online2 August 2016AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 20 Feb 2017 12:14 Last modified: 16 Oct 2024 00:27 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/59868