Regioselective magnesiation of N-heterocyclic molecules: securing insecure cyclic anions by a β-diketiminate-magnesium clamp
Davin, Laia and McLellan, Ross and Hernán-Gómez, Alberto and Clegg, Bill and Kennedy, A R and Stepek, Iain and Mertens, Maria and Hevia, Eva (2017) Regioselective magnesiation of N-heterocyclic molecules: securing insecure cyclic anions by a β-diketiminate-magnesium clamp. Chemical Communications. ISSN 1359-7345
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Abstract
Using a specially designed magnesium metallating manifold, combining kinetically activated TMP amide base with a sterically amplified β-diketiminate ligand, this study has established a new regioselective strategy for magnesiation of challenging N-heterocyclic molecules. The broad scope of the approach is illustrated through reactions of pyrazine, triazoles and substituted pyridines through isolation and structural elucidation of their magnesiated intermediates.
Creators(s): |
Davin, Laia ![]() ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 59343 |
Keywords: | magnesium metallating manifold, regioselective strategy , magnesiation, N-heterocyclic molecules, synthesis, chrage density, deprotonative metalation, Chemistry, Chemistry(all) |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 10 Jan 2017 10:32 |
Last modified: | 24 Feb 2021 08:41 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/59343 |
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