New avenues for drug delivery in Leishmania: using treatment of visceral leishmaniasis with amphotericin B as an exemplar.

Carter, Katharine and Mullen, Alexander (2016) New avenues for drug delivery in Leishmania: using treatment of visceral leishmaniasis with amphotericin B as an exemplar. In: Drug Discovery in Leishmaniasis. Royal Society of Chemistry. (In Press)

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Abstract

In this review the benefits of using a drug delivery system (DDS) to improve therapeutic outcome will be discussed using treatment of visceral leishmaniasis with amphotericin B (AMB), a poorly water soluble drug, as an exemplar. Progress in producing AMB formulations that can be given by intravenous, oral and pulmonary routes of administration is discussed.