Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping

Uzelac, Marina and Kennedy, Alan R. and Hevia, Eva and Mulvey, Robert E. (2016) Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping. Angewandte Chemie International Edition, 55. pp. 13147-13150. ISSN 1433-7851

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    Abstract

    This study establishes a new trans-metal-trapping (TMT) protocol based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2SiMe3)3, GaR3] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution as illustrated through reactions of pyrazine, pyridazine and pyrimidine, as well as through the N-S heterocycle benzothiazole, the metallo-activated complexes of all of which have been isolated and structurally defined.

    Creators(s): Uzelac, Marina ORCID logoORCID: https://orcid.org/0000-0002-5060-7017, Kennedy, Alan R. ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Hevia, Eva ORCID logoORCID: https://orcid.org/0000-0002-3998-7506 and Mulvey, Robert E. ORCID logoORCID: https://orcid.org/0000-0002-1015-2564;
    Item type:Article
    ID code:57758
    Notes:This is the peer reviewed version of the following article: Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping. / Uzelac, Marina; Kennedy, Alan R.; Hevia, Eva; Mulvey, Robert E. In: Angewandte Chemie International Edition, 06.09.2016., which has been published in final form at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Keywords:trans-metal-trapping, TMT, sensitive diazines, LiTMP lithiation, Physical and theoretical chemistry, Physical and Theoretical Chemistry
    Subjects:Science > Chemistry > Physical and theoretical chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:12 Sep 2016 11:41
    Last modified:10 Nov 2020 04:07
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/57758
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