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Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping

Uzelac, Marina and Kennedy, Alan R. and Hevia, Eva and Mulvey, Robert E. (2016) Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping. Angewandte Chemie International Edition, 55. pp. 13147-13150. ISSN 1433-7851

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Abstract

This study establishes a new trans-metal-trapping (TMT) protocol based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2SiMe3)3, GaR3] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution as illustrated through reactions of pyrazine, pyridazine and pyrimidine, as well as through the N-S heterocycle benzothiazole, the metallo-activated complexes of all of which have been isolated and structurally defined.

Item type: Article
ID code: 57758
Notes: This is the peer reviewed version of the following article: Transforming LiTMP lithiation of challenging diazines via gallium alkyl trans-metal-trapping. / Uzelac, Marina; Kennedy, Alan R.; Hevia, Eva; Mulvey, Robert E. In: Angewandte Chemie International Edition, 06.09.2016., which has been published in final form at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: trans-metal-trapping, TMT, sensitive diazines, LiTMP lithiation, Physical and theoretical chemistry, Physical and Theoretical Chemistry
Subjects: Science > Chemistry > Physical and theoretical chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited: 12 Sep 2016 11:41
Last modified: 05 Apr 2019 20:41
Related URLs:
URI: https://strathprints.strath.ac.uk/id/eprint/57758
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