Viedma ripening : a reliable crystallisation method to reach single chirality

Sögütoglu, Leyla-Cann and Steendam, René R. E. and Meekes, Hugo and Vlieg, Elias and Rutjes, Floris P. J. T. (2015) Viedma ripening : a reliable crystallisation method to reach single chirality. Chemical Society Reviews, 44 (19). pp. 6723-6732. ISSN 0306-0012

[img]
Preview
Text (Sögütoglu-etal-CSR-2015-Viedma-ripening-a-reliable-crystallisation-method)
S_g_toglu_etal_CSR_2015_Viedma_ripening_a_reliable_crystallisation_method.pdf
Final Published Version
License: Creative Commons Attribution 3.0 logo

Download (3MB)| Preview

    Abstract

    Crystallisation processes have evolved to practical methods that allow isolation of an enantiopure product in high yield. Viedma ripening in particular enables access to enantiopure products in a reliable way, simply through grinding of crystals in a solution. This tutorial review covers the basic principles behind asymmetric crystallisation processes, with an emphasis on Viedma ripening, and shows that to date many novel organic molecules can be obtained in enantiopure solid form.