Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Tawfike, Ahmed Fares and Edrada-Ebel, Ruangelie and Tate, Roth and Diederich, Marc and Schumacher, Marc and Sawadogo, Richard and Clements, Carol and Young, Louise (2014) Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs. In: Metabolomics 2014, 2014-06-23 - 2014-06-26, Daiichi Hotel Tsuruoka and Marica/Washington Hotel.

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Abstract

This study involved bioassay guided chromatographic isolation of three new natural compounds with 40 known bio-active metabolites from three endophytic fungi from different Egyptian medicinal plants. Identification of the strain has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liquid culture media. Dereplication studies were accomplished by utilizing the Mzmine software with the AntiBase database. The chemometric algorithms using SIMCA-P+ software were used to compare the active and inactive extracts and/or fractions in order to early predict the bioactive metabolites

Author(s):Tawfike, Ahmed Fares ORCID: https://orcid.org/0000-0003-2061-3093, Edrada-Ebel, Ruangelie, Tate, Roth, Diederich, Marc, Schumacher, Marc, Sawadogo, Richard, Clements, Carol and Young, Louise
Item type:Conference or Workshop Item(Poster)
ID code:56999
Keywords:bioactive metabolites, Egyptian medicinal plants, anti cancer drugs, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:20 Jul 2016 13:10
Last modified:23 Aug 2019 01:03
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URI:https://strathprints.strath.ac.uk/id/eprint/56999
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