Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment

Agnew, Lauren R. and Cruickshank, Dyanne L. and McGlone, Thomas and Wilson, Chick C. (2016) Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment. Chemical Communications, 52 (46). pp. 7368-7371. ISSN 1359-7345

[img]
Preview
Text (Agnew-etal-CC2016-Controlled-production-of-the-elusive-metastable-form-II-of-acetaminophen-(paracetamol))
Agnew_etal_CC2016_Controlled_production_of_the_elusive_metastable_form_II_of_acetaminophen_paracetamol_.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (1MB)| Preview

    Abstract

    A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.