Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment
Agnew, Lauren R. and Cruickshank, Dyanne L. and McGlone, Thomas and Wilson, Chick C. (2016) Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment. Chemical Communications, 52 (46). pp. 7368-7371. ISSN 1359-7345 (https://doi.org/10.1039/c6cc01032f)
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Abstract
A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
ORCID iDs
Agnew, Lauren R., Cruickshank, Dyanne L., McGlone, Thomas ORCID: https://orcid.org/0000-0002-9897-1790 and Wilson, Chick C.;-
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Item type: Article ID code: 56852 Dates: DateEvent11 June 2016Published19 February 2016Published Online19 February 2016AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 06 Jul 2016 11:10 Last modified: 01 Oct 2024 00:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56852
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