Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug
Kastner, Elisabeth and Verma, Varun and Lowry, Deborah and Perrie, Yvonne (2015) Microfluidic-controlled manufacture of liposomes for the solubilisation of a poorly water soluble drug. International Journal of Pharmaceutics, 485 (1-2). pp. 122-130. ISSN 1873-3476 (https://doi.org/10.1016/j.ijpharm.2015.02.063)
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Abstract
Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidics, to prepare liposomal solubilising systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasise the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilisation of poorly water-soluble drugs.
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Item type: Article ID code: 56754 Dates: DateEvent15 May 2015Published25 February 2015Published Online24 February 2015AcceptedNotes: Copyright © 2015 Elsevier B.V. All rights reserved. Subjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 28 Jun 2016 10:46 Last modified: 07 Oct 2024 07:26 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56754