Designing liposomal adjuvants for the next generation of vaccines

Perrie, Yvonne and Crofts, Fraser and Devitt, Andrew and Griffiths, Helen R. and Kastner, Elisabeth and Nadella, Vinod (2016) Designing liposomal adjuvants for the next generation of vaccines. Advanced Drug Delivery Reviews, 99 (Pt A). pp. 85-96. ISSN 0169-409X

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    Abstract

    Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via a range of administration routes. In the development of liposomal adjuvants, the type of immune response promoted has been linked to their physico-chemical characteristics, with the size and charge of the liposomal particles impacting on liposome biodistribution, exposure in the lymph nodes and recruitment of the innate immune system. The addition of immunostimulatory agents can further potentiate their immunogenic properties. Here, we outline the attributes that should be considered in the design and manufacture of liposomal adjuvants for the delivery of sub-unit and nucleic acid based vaccines.

    • Item type:Article
      ID code:56753
      Dates:
      Date
      Event
      1 April 2016
      Published
      11 November 2015
      Published Online
      5 November 2015
      Accepted
      Notes:© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
      Keywords:liposomes, vaccines, adjuvants, antigens, delivery systems, microfluidics, qbd, mva, immunostimulatory agents, nucleic acid, quality by design, multivariate analysis, Therapeutics. Pharmacology, Pharmaceutical Science, SDG 3 - Good Health and Well-being
      Subjects:Medicine > Therapeutics. Pharmacology
      Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
      Depositing user: Pure Administrator
      Date deposited:28 Jun 2016 10:46
      Last modified:23 Sep 2021 05:38
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/56753
    CORE (COnnecting REpositories)