A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery
McCormick, Christopher and Jones, Robert L. and Wadsworth, Roger M. and Mullen, Alexander B. and Kennedy, Simon (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy. ISSN 2157-9431 (In Press)
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Abstract
Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study we implanted stents coated with cicaprost, a prostacyclin analogue with a long plasma half-life and antiproliferative effects on vascular smooth muscle cells, into the iliac arteries of rabbits. At 28 day follow-up we compared neointima formation within the stented vessels and vascular function in adjacent vessels, to assess if cicaprost could reduce restenosis without impairing vessel function. Arteries implanted with cicaprost eluting stents had significantly more neointima compared to bare metal stents. In adjacent segments of artery, endothelium-dependent relaxation was impaired by the cicaprost-eluting stent but vasodilation to an endothelium-independent vasodilator was maintained. We conclude that the presence of the polymer and sub-optimal release of cicaprost from the stent may be responsible for the increased neointma and impaired functional recovery of the endothelium observed. Further experiments should be aimed at optimising release of cicaprost and exploring different stent polymer coatings.
ORCID iDs
McCormick, Christopher, Jones, Robert L., Wadsworth, Roger M., Mullen, Alexander B. ORCID: https://orcid.org/0000-0001-7475-5543 and Kennedy, Simon;-
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Item type: Article ID code: 56716 Dates: DateEvent13 June 2016Published13 June 2016AcceptedSubjects: Medicine > Therapeutics. Pharmacology Department: Faculty of Engineering > Biomedical Engineering
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical SciencesDepositing user: Pure Administrator Date deposited: 22 Jun 2016 09:29 Last modified: 23 Sep 2024 00:41 URI: https://strathprints.strath.ac.uk/id/eprint/56716