Effect of changing from first- to second- line antiretroviral therapy on renal function : a retrospective study based on data from a single health facility in Namibia
Kalemeera, Francis and Mbango, Christofina and Mubita, Mwangana and Naikaku, Esther and Gaida, Razia and Godman, Brian (2016) Effect of changing from first- to second- line antiretroviral therapy on renal function : a retrospective study based on data from a single health facility in Namibia. Expert Review of Anti-infective Therapy, 14 (8). pp. 777-783. ISSN 1744-8336 (https://doi.org/10.1080/14787210.2016.1202759)
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Abstract
Tenofovir disoproxil fumarate (TDF) and lopinavir/ritonavir (LPV/r) can cause renal impairment with this combination co-administered during second-line combination antiretroviral therapy (cART) potentially associated with greater risk of nephrotoxicity. Objective: Assess effects of second-line cART on renal function. Methods: Retrospective longitudinal study in patients receiving cART. Results: 71 patients received TDF, zidovudine or stavudine, each combined with 3TC/NVP or 3TC/ EFV. Before second-line cART, 46.5% had abnormal kidney function. First-line cART had no relationship with calculated creatinine clearance (CrCl). During second-line cART, more males than females had abnormal renal function and more females experienced increases in CrCl. Calculated CrCl during second-line cART related strongly with CrCl during first-line cART; time spent on cART weak relationship with CrCl. Conclusion: Patients on first-line cART for several years without renal impairment may experience new onset impairment during cART. Patients with pre-existing renal impairment just before switching to second-line cART may experience a further decline.
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Item type: Article ID code: 56694 Dates: DateEvent14 July 2016Published14 June 2016Accepted25 January 2016SubmittedNotes: Kalemeera, F., Mbango, C., Mubita, M., Naikaku, E., Gaida, R., & Godman, B. (2016). Effect of changing from first- to second-line antiretroviral therapy on renal function: a retrospective study based on data from a single health facility in Namibia. Expert Review of Anti-Infective Therapy, 14(8), 777–783. https://doi.org/10.1080/14787210.2016.1202759 Subjects: Medicine > Pharmacy and materia medica
MedicineDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 17 Jun 2016 15:18 Last modified: 11 Jun 2024 07:08 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56694