Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol
Caldwell, Nicola and Jamieson, Craig and Simpson, Iain and Watson, Allan J B (2015) Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol. Chemical Communications, 51 (46). pp. 9495-9498. ISSN 1359-7345 (https://doi.org/10.1039/c5cc02895g)
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Abstract
A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.
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Item type: Article ID code: 55933 Dates: DateEvent11 June 2015Published8 May 2015Published Online8 May 2015AcceptedSubjects: Science > Chemistry Department: University of Strathclyde > University of Strathclyde
Faculty of Science > Pure and Applied ChemistryDepositing user: Pure Administrator Date deposited: 17 Mar 2016 16:03 Last modified: 28 Jul 2024 16:02 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/55933
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