Vitamin D status and ill health--author's reply

Autier, Philippe and Boniol, Mathieu and Pizot, Cécile and Mullie, Patrick (2014) Vitamin D status and ill health--author's reply. The Lancet Diabetes & Endocrinology, 2 (4). pp. 275-276.

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Abstract

Giovannucci enquires whether intervention studies were long enough to allow full expression of health benefits associated with high serum 25-hydroxyvitamin D (25[OH]D) concentrations. Recent meta-analyses that compared top to bottom quantiles of 25(OH)D found summary relative risks of 0·67 (95% CI: 0·59–0·75) in 16 studies of type 2 diabetes1 and of 0·66 (0·54–0·81) in eight studies of colorectal cancer.2 We plotted relative risks of diabetes and colorectal cancer occurrence reported by prospective studies against follow-up duration (figure).