The risk of developing a second primary cancer in melanoma patients : a comprehensive review of the literature and meta-analysis
Caini, Saverio and Boniol, Mathieu and Botteri, Edoardo and Tosti, Giulio and Bazolli, Barbara and Russell-Edu, William and Giusti, Francesco and Testori, Alessandro and Gandini, Sara (2014) The risk of developing a second primary cancer in melanoma patients : a comprehensive review of the literature and meta-analysis. Journal of Dermatological Science, 75 (1). pp. 3-9. ISSN 1873-569X (https://doi.org/10.1016/j.jdermsci.2014.02.007)
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The number of cutaneous melanoma survivors has been increasing for years due to improvements in early diagnosis and subsequent prolonged survival. These patients are at increased risk of developing a second melanoma and a second primary malignancy (SPM) at other sites as well. We performed a review of scientific literature and meta-analysis to evaluate the risk of developing a SPM (other than melanoma) among melanoma patients. Twenty-three independent papers and over 350,000 melanoma patients were included. Risk of cancer among melanoma survivors was increased overall (1.57, 95% CI 1.29-1.90) and at several sites: bone (2.09, 95% CI 1.08-4.05), non-melanoma skin cancer (4.01, 95% CI 1.81-8.87), soft tissue (6.80, 95% CI 1.29-35.98), colon-rectum (1.12, 95% CI 1.00-1.25), female breast (1.14, 95% CI 1.07-1.22), kidney (1.34, 95% CI 1.23-1.45), prostate (1.25, 95% CI 1.13-1.37) and non-Hodgkin lymphoma (1.37, 95% CI 1.22-1.54). The overall risk of SPM showed a tendency to decrease as the time from melanoma diagnosis lengthened. Most of our findings may be explained by the tendency of some exposures, which are risk factors for different tumors, to occur simultaneously in the same individuals. These results suggest primary and secondary cancer prevention counselling for melanoma survivors.
ORCID iDs
Caini, Saverio, Boniol, Mathieu ORCID: https://orcid.org/0000-0001-6585-4443, Botteri, Edoardo, Tosti, Giulio, Bazolli, Barbara, Russell-Edu, William, Giusti, Francesco, Testori, Alessandro and Gandini, Sara;-
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Item type: Article ID code: 55328 Dates: DateEvent1 July 2014Published5 March 2014Published Online23 February 2014AcceptedNotes: Copyright © 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. Subjects: Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer)
Medicine > Pharmacy and materia medicaDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 14 Jan 2016 15:57 Last modified: 07 Oct 2024 03:59 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/55328