One-pot homologation of boronic acids : a platform for diversity-oriented synthesis

Muir, Calum W. and Vantourout, Julien C. and Isidro-Llobet, Albert and Macdonald, Simon J. F. and Watson, Allan J. B. (2015) One-pot homologation of boronic acids : a platform for diversity-oriented synthesis. Organic Letters, 17 (24). 6030–6033. ISSN 1523-7060 (https://doi.org/10.1021/acs.orglett.5b03030)

Preview

Text. Filename: Muir_etal_OL_2015_One_pot_homologation_of_boronic_acids_a_platform_for_diversity.pdf Final Published Version License: Download (740kB)| Preview

Abstract

Formal homologation of sp2-hybridized boronic acids is achieved via cross-coupling of boronic acids with conjunctive haloaryl BMIDA components in the presence of a suitably balanced basic phase. The utility of this approach to provide a platform for diversity-oriented synthesis in discovery medicinal chemistry is demonstrated in the context of the synthesis of a series of analogues of a BET bromodomain inhibitor.

• Share and Export
  

  RDF+XMLBibTeXRIOXX2 XMLRDF+N-TriplesJSONDublin CoreAtomSimple MetadataReferMETSHTML CitationASCII CitationOpenURL ContextObjectEndNoteOpenURL ContextObject in SpanMODSMPEG-21 DIDLEP3 XMLData Cite XMLRIS (EndNote Online, Zotero, Ref manager, etc)RDF+N3Multiline CSV
• Item metadata

  Item type:	Article
  ID code:	54860
  Dates:	Date Event 3 December 2015 Published 1 December 2015 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	11 Dec 2015 01:49
  Last modified:	09 Apr 2024 08:21
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/54860