Copper complexes as a source of redox active MRI contrast agents

Dunbar, Lynsey and Sowden, Rebecca J. and Trotter, Katherine D. and Taylor, Michelle K. and Smith, David and Kennedy, Alan R. and Reglinski, John and Spickett, Corinne M. (2015) Copper complexes as a source of redox active MRI contrast agents. BioMetals, 28. pp. 903-912. ISSN 0966-0844

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    Abstract

    The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.