Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach
Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060
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Abstract
Two advances in the synthesis of hairpin pyrrole-imidazole polyamides (PAs) are described. First, the application of a convergent synthetic strategy is shown, involving the Boc-based solid phase synthesis of a C-terminal fragment and the solution phase synthesis of the N-terminal fragment. Second a new hybrid resin is developed that allows for the preparation of hairpin PAs lacking a C-terminal β-alanine tail. Both methods are compatible with a range of coupling reagents and provide a facile, modular route to prepare PA libraries in high yield and crude purity.
Creators(s): | Fallows, Andrew J., Singh, Ishwar, Dondi, Ruggero, Cullis, Paul M. and Burley, Glenn A.; | Item type: | Article |
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ID code: | 54069 |
Keywords: | hairpin pyrrole-imidazole polyamides , convergent synthetic strategy, DNA binding polymides, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology |
Depositing user: | Pure Administrator |
Date deposited: | 25 Aug 2015 14:48 |
Last modified: | 20 Feb 2021 02:08 |
URI: | https://strathprints.strath.ac.uk/id/eprint/54069 |
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