Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach
Fallows, Andrew J. and Singh, Ishwar and Dondi, Ruggero and Cullis, Paul M. and Burley, Glenn A. (2014) Highly efficient synthesis of DNA-binding polyamides using a convergent fragment-based approach. Organic Letters, 16 (17). pp. 4654-4657. ISSN 1523-7060
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Abstract
Two advances in the synthesis of hairpin pyrrole-imidazole polyamides (PAs) are described. First, the application of a convergent synthetic strategy is shown, involving the Boc-based solid phase synthesis of a C-terminal fragment and the solution phase synthesis of the N-terminal fragment. Second a new hybrid resin is developed that allows for the preparation of hairpin PAs lacking a C-terminal β-alanine tail. Both methods are compatible with a range of coupling reagents and provide a facile, modular route to prepare PA libraries in high yield and crude purity.
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Item type: Article ID code: 54069 Dates: DateEvent5 September 2014Published27 August 2014Published Online27 August 2014AcceptedKeywords: hairpin pyrrole-imidazole polyamides , convergent synthetic strategy, DNA binding polymides, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 25 Aug 2015 14:48 Last modified: 12 Jul 2021 08:05 URI: https://strathprints.strath.ac.uk/id/eprint/54069
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