Lysophosphatidic acid and sphingosine 1-phosphate biology : the role of lipid phosphate phosphatases
Pyne, Susan and Kong, Kok-Choi and Darroch, Peter I (2004) Lysophosphatidic acid and sphingosine 1-phosphate biology : the role of lipid phosphate phosphatases. Seminars in Cell and Developmental Biology, 15 (5). pp. 491-501. ISSN 1084-9521 (https://doi.org/10.1016/j.semcdb.2004.05.007)
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The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.
ORCID iDs
Pyne, Susan ORCID: https://orcid.org/0000-0002-6608-9584, Kong, Kok-Choi and Darroch, Peter I;-
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Item type: Article ID code: 49548 Dates: DateEventOctober 2004Published1 July 2004Published OnlineSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 03 Oct 2014 12:14 Last modified: 02 Dec 2024 01:15 URI: https://strathprints.strath.ac.uk/id/eprint/49548