New bromopyrrole alkaloids from the marine sponges axinella damicornis and stylissa flabelliformis

Hassan, Wafaa and Elkhayat, Ehab S. and Edrada, Ru AnGelie and Ebel, Rainer and Proksch, Peter (2007) New bromopyrrole alkaloids from the marine sponges axinella damicornis and stylissa flabelliformis. Natural Product Communications, 2 (11). pp. 1149-1154. ISSN 1934-578X

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Abstract

Investigation of the tropical sponges Axinella damicornis and Stylissa flabelliformis, family Axinillidae, afforded five new bromopyrrole alkaloids (1-5) and thirteen known compounds (6-18). Semi synthesis of S was carried out in order to confirm its structure. The structures of the isolated compounds were elucidated using ID- And 2D-NMR spectroscopy and mass spectrometry. The cytotoxicity, antimicrobial and protein-kinase inhibition activities were tested for the isolated compounds.