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Leishmania MAP kinases-familiar proteins in an unusual context

Wiese, Martin (2007) Leishmania MAP kinases-familiar proteins in an unusual context. International Journal for Parasitology, 37 (10). pp. 1053-62. ISSN 0020-7519

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Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.