Picture water droplets

Developing mathematical theories of the physical world: Open Access research on fluid dynamics from Strathclyde

Strathprints makes available Open Access scholarly outputs by Strathclyde's Department of Mathematics & Statistics, where continuum mechanics and industrial mathematics is a specialism. Such research seeks to understand fluid dynamics, among many other related areas such as liquid crystals and droplet evaporation.

The Department of Mathematics & Statistics also demonstrates expertise in population modelling & epidemiology, stochastic analysis, applied analysis and scientific computing. Access world leading mathematical and statistical Open Access research!

Explore all Strathclyde Open Access research...

Microneedle/nanoencapsulation-mediated transdermal delivery : mechanistic insights

Gomaa, Yasmine A. and Garland, Martin J. and McInnes, Fiona J. and Donnelly, Ryan F. and El-Khordagui, Labiba K. and Wilson, Clive G. (2014) Microneedle/nanoencapsulation-mediated transdermal delivery : mechanistic insights. European Journal of Pharmaceutics and Biopharmaceutics, 86 (2). pp. 145-155. ISSN 0939-6411

[img]
Preview
PDF (Gomaa-etal-EJPB2014-microneedle-nanoencapsulation-mediated-transdermal)
Gomaa_etal_EJPB2014_microneedle_nanoencapsulation_mediated_transdermal.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo

Download (1MB) | Preview

Abstract

A systematic study was undertaken to gain more insight into the mechanism of transdermal delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex process not yet explored. Rhodamine B (Rh B) and fluorescein isothiocyanate (FITC) as model hydrophilic and hydrophobic small/medium-size molecules, respectively, were encapsulated in poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) and delivered through full thickness porcine skin pretreated with MN array. Permeation through MN-treated skin was affected by physicochemical characteristics of NPs and the encapsulated dyes. Dye flux was enhanced by smaller particle size, hydrophilicity, and negative zeta potential of NPs. Regarding encapsulated dyes, solubility at physiological pH and potential interaction with skin proteins proved to outweigh molecular weight as determinants of skin permeation. Data were verified using confocal laser scanning microscopy imaging. Findings coupled with the literature data are supportive of a mechanism involving influx of NPs, particularly of smaller size, deep into MN-created channels, generating depot dye-rich reservoirs. Molecular diffusion of the released dye across viable skin layers proceeds at a rate determined by its molecular characteristics. Data obtained provide mechanistic information of importance to the development of formulation strategies for more effective intradermal and transdermal MN-mediated delivery of nanoencapsulated therapeutic agents.