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Bioactive terpenes from the soft coral Heteroxenia sp. from Mindoro, Philippines

Edrada-Ebel, Ruangelie and Wray, V and Witte, L and van Ofwegen, L and Proksch, P (2000) Bioactive terpenes from the soft coral Heteroxenia sp. from Mindoro, Philippines. Zeitschrift fur Naturforschung C, 55 (1-2). pp. 82-86. ISSN 0939-5075

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Abstract

A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-alpha-muurolene (1) and a novel derivative (+)-6-hydroxy-alpha-muurolene (2), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long range 13C-1H correlations) and mass spectrometric (EIMS) data. All compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. The isolated terpenes were also active in the brine shrimp lethality test.