Isolation and structure elucidation of ardisenone : a new, cytotoxic alkenylphenol from Ardisia iwahigensis
Horgen, F D and Guinaudeau, H and Pezzuto, J M and Soejarto, D D and Farnsworth, N R and Agcaoili, F and de los Reyes, G and Edrada, R A and Edrada-Ebel, Ruangelie (1997) Isolation and structure elucidation of ardisenone : a new, cytotoxic alkenylphenol from Ardisia iwahigensis. Journal of Natural Products, 60 (5). pp. 533-535. ISSN 0163-3864
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A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.
Creators(s): | Horgen, F D, Guinaudeau, H, Pezzuto, J M, Soejarto, D D, Farnsworth, N R, Agcaoili, F, de los Reyes, G, Edrada, R A and Edrada-Ebel, Ruangelie; | Item type: | Article |
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ID code: | 48603 |
Keywords: | animals, anisoles, antineoplastic agents, phytogenic, artemia, drug screening assays, antitumor, humans, magnetic resonance spectroscopy, plant extracts, plants, Medicinal, spectrophotometry, infrared, tumor cells, cultured, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 17 Jun 2014 11:28 |
Last modified: | 20 Jan 2021 21:19 |
URI: | https://strathprints.strath.ac.uk/id/eprint/48603 |
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