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Isolation and structure elucidation of ardisenone : a new, cytotoxic alkenylphenol from Ardisia iwahigensis

Horgen, F D and Guinaudeau, H and Pezzuto, J M and Soejarto, D D and Farnsworth, N R and Agcaoili, F and de los Reyes, G and Edrada, R A and Edrada-Ebel, Ruangelie (1997) Isolation and structure elucidation of ardisenone : a new, cytotoxic alkenylphenol from Ardisia iwahigensis. Journal of Natural Products, 60 (5). pp. 533-535. ISSN 0163-3864

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Abstract

A methanol extract of leaves and twigs from Ardisia iwahigensis demonstrated toxicity toward brine shrimp as well as LNCaP, ZR-75-1, and Lu1 human cancer cells in culture. A novel alkenylphenol, (Z)-1,16-bis(3-hydroxy-5-methoxyphenyl)-10-hexadecene-1,15-dione (ardisenone) (1), was isolated from the extract by bioassay-directed fractionation. This compound demonstrated moderate cytotoxicity against BC1, Lu1, Col2, KB, KB-V1, and LNCaP cell lines.