New sesquiterpene quinols from a Micronesian sponge, Aka sp

Mukku, Venugopal J R V and Edrada-Ebel, Ruangelie and Schmitz, Francis J and Shanks, Michelle Kelly and Chaudhuri, Babathosh and Fabbro, Doriano (2003) New sesquiterpene quinols from a Micronesian sponge, Aka sp. Journal of Natural Products, 66 (5). pp. 686-689. ISSN 0163-3864

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Abstract

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.

Author(s):Mukku, Venugopal J R V, Edrada-Ebel, Ruangelie, Schmitz, Francis J, Shanks, Michelle Kelly, Chaudhuri, Babathosh and Fabbro, Doriano
Item type:Article
ID code:48494
Keywords:animals, chromatography, high pressure liquid, cyclin D1, cyclin dependent kinase 4, cyclin dependent kinases, inhibitory concentration 50, micronesia, molecular structure, biomolecular nuclear magnetic resonance, porifera, proto-oncogene proteins, sesquiterpenes, Chemistry, Microbiology, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Science > Chemistry
Science > Microbiology
Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:11 Jun 2014 13:03
Last modified:03 Jan 2019 14:02
URI:https://strathprints.strath.ac.uk/id/eprint/48494
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