New sesquiterpene quinols from a Micronesian sponge, Aka sp

Mukku, Venugopal J R V and Edrada-Ebel, Ruangelie and Schmitz, Francis J and Shanks, Michelle Kelly and Chaudhuri, Babathosh and Fabbro, Doriano (2003) New sesquiterpene quinols from a Micronesian sponge, Aka sp. Journal of Natural Products, 66 (5). pp. 686-689. ISSN 0163-3864

Full text not available in this repository.Request a copy from the Strathclyde author

Abstract

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.