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Uniquely modified imidazole alkaloids from a calcareous Leucetta sponge

Edrada-Ebel, Ruangelie and Stessman, Chad C and Crews, Phillip (2003) Uniquely modified imidazole alkaloids from a calcareous Leucetta sponge. Journal of Natural Products, 66 (7). pp. 939-942. ISSN 0163-3864

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Abstract

A Fijian collection of the calcareous sponge Leucetta sp. was investigated and yielded four new imidazole alkaloids. One compound, (+)-calcaridine A (6), is unique in its overall structure and consists of a geminally substituted 2-aminoimidazolidinone. An additional compound, (-)-spirocalcaridine A (7), is distinctive in its hexahydrocyclopentamidazol-2-ylidenamine spiro-linked to a cyclohexenone. A third compound, (-)-spirocalcaridine B (8), is the OCH(3) analogue of 7. These compounds have unprecedented skeletons and functionality and are the first nonorganometalic chiral aminoimidazoles isolated from calcareous sponges. The two issues discussed here include the challenges associated with the structure elucidations of 6 and 7 and the relationships to previously encountered Leucetta metabolites.