Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp.

Schupp, Peter and Poehner, Timo and Edrada-Ebel, Ruangelie and Ebel, Rainer and Berg, Albrecht and Wray, Victor and Proksch, Peter (2003) Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp. Journal of Natural Products, 66 (2). pp. 272-275. ISSN 0163-3864

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Abstract

Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity.

Author(s):Schupp, Peter, Poehner, Timo, Edrada-Ebel, Ruangelie, Ebel, Rainer, Berg, Albrecht, Wray, Victor and Proksch, Peter
Item type:Article
ID code:48480
Keywords:animals, anti-bacterial agents, anti-infective agents, antifungal agents, bacillus subtilis, candida albicans, carbolines, escherichia coli, micronesia, molecular structure, nuclear magnetic resonance, biomolecular, spectrometry, mass, electrospray ionization, staphylococcus aureus, urochordata, Chemistry, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Science > Chemistry
Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:09 Jun 2014 15:44
Last modified:06 Sep 2019 03:15
URI:https://strathprints.strath.ac.uk/id/eprint/48480
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