Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Strathprints

A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara

El-Sayed Hamed, Ashraf Nageeb and Wätjen, Wim and Schmitz, Roland and Chovolou, Yvonni and Edrada-Ebel, Ruangelie and Youssef, Diaa T A and Kamel, Mohammed Salah and Proksch, Peter (2013) A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara. Natural Product Communications, 8 (3). pp. 289-292. ISSN 1934-578X

Full text not available in this repository.Request a copy from the Strathclyde author

Abstract

Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.

Item type:Article
ID code:48464
Keywords:cytotoxicity, dysidea avara, insecticidial activity, NF-κB, protein kinase inhibition, sesquiterpene, Pharmacy and materia medica, Drug Discovery, Pharmacology, Complementary and alternative medicine, Plant Science
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:06 Jun 2014 14:12
Last modified:03 Jan 2019 14:02
Related URLs:
URI:https://strathprints.strath.ac.uk/id/eprint/48464
Export data:
CORE (COnnecting REpositories)