A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara

El-Sayed Hamed, Ashraf Nageeb and Wätjen, Wim and Schmitz, Roland and Chovolou, Yvonni and Edrada-Ebel, Ruangelie and Youssef, Diaa T A and Kamel, Mohammed Salah and Proksch, Peter (2013) A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara. Natural Product Communications, 8 (3). pp. 289-292. ISSN 1934-578X

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Abstract

Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.