A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara
El-Sayed Hamed, Ashraf Nageeb and Wätjen, Wim and Schmitz, Roland and Chovolou, Yvonni and Edrada-Ebel, Ruangelie and Youssef, Diaa T A and Kamel, Mohammed Salah and Proksch, Peter (2013) A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara. Natural Product Communications, 8 (3). pp. 289-292. ISSN 1934-578X
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Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.
Creators(s): | El-Sayed Hamed, Ashraf Nageeb, Wätjen, Wim, Schmitz, Roland, Chovolou, Yvonni, Edrada-Ebel, Ruangelie, Youssef, Diaa T A, Kamel, Mohammed Salah and Proksch, Peter; | Item type: | Article |
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ID code: | 48464 |
Keywords: | cytotoxicity, dysidea avara, insecticidial activity, NF-κB, protein kinase inhibition, sesquiterpene, Pharmacy and materia medica, Drug Discovery, Pharmacology, Complementary and alternative medicine, Plant Science |
Subjects: | Medicine > Pharmacy and materia medica |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 06 Jun 2014 14:12 |
Last modified: | 05 Sep 2020 02:32 |
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URI: | https://strathprints.strath.ac.uk/id/eprint/48464 |
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