New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Jadulco, Raquel and Edrada, Ru Angelie and Ebel, Rainer and Berg, Albrecht and Schaumann, Karsten and Wray, Victor and Steube, Klaus and Proksch, Peter and Edrada-Ebel, Ruangelie (2004) New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa. Journal of Natural Products, 67 (1). pp. 78-81. ISSN 0163-3864

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Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

Creators(s): Jadulco, Raquel, Edrada, Ru Angelie, Ebel, Rainer, Berg, Albrecht, Schaumann, Karsten, Wray, Victor, Steube, Klaus, Proksch, Peter and Edrada-Ebel, Ruangelie;
Item type:Article
ID code:48454
Keywords:Animals, antineoplastic agents, artemia, drug screening assays, griseofulvin, heterocyclic compounds with 4 or More Rings, Italy, Mediterranean Sea, molecular structure, nuclear magnetic resonance, penicillium, porifera, stereoisomerism, tumor cells, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:06 Jun 2014 09:21
Last modified:03 Jul 2020 00:55
URI:https://strathprints.strath.ac.uk/id/eprint/48454
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