New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Jadulco, Raquel and Edrada, Ru Angelie and Ebel, Rainer and Berg, Albrecht and Schaumann, Karsten and Wray, Victor and Steube, Klaus and Proksch, Peter and Edrada-Ebel, Ruangelie (2004) New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa. Journal of Natural Products, 67 (1). pp. 78-81. ISSN 0163-3864

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Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

  • Item type:Article
    ID code:48454
    Dates:
    Date
    Event
    January 2004
    Published
    Keywords:Animals, antineoplastic agents, artemia, drug screening assays, griseofulvin, heterocyclic compounds with 4 or More Rings, Italy, Mediterranean Sea, molecular structure, nuclear magnetic resonance, penicillium, porifera, stereoisomerism, tumor cells, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:06 Jun 2014 09:21
    Last modified:20 Jan 2021 21:19
    URI:https://strathprints.strath.ac.uk/id/eprint/48454
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