New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata

Yasman, Yasman and Edrada, Ru Angelie and Wray, Victor and Proksch, Peter and Edrada-Ebel, Ruangelie (2003) New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata. Journal of Natural Products, 66 (11). pp. 1512-1514. ISSN 0163-3864

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Abstract

Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC(50) of 5 ppm. At a dose level of 20 microg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

  • Item type:Article
    ID code:48453
    Dates:
    Date
    Event
    November 2003
    Published
    Keywords:animals, Artemia, bacillus subtilis, candida albicans, escherichia coli, Indonesia, microbial sensitivity tests, molecular structure, mollusca, nuclear magnetic resonance, porifera, sesquiterpenes, staphylococcus aureus, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
    Subjects:Medicine > Therapeutics. Pharmacology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:06 Jun 2014 09:15
    Last modified:11 Jun 2021 03:02
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/48453
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