New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata

Yasman, Yasman and Edrada, Ru Angelie and Wray, Victor and Proksch, Peter and Edrada-Ebel, Ruangelie (2003) New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata. Journal of Natural Products, 66 (11). pp. 1512-1514. ISSN 0163-3864

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Abstract

Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC(50) of 5 ppm. At a dose level of 20 microg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

Author(s):Yasman, Yasman, Edrada, Ru Angelie, Wray, Victor, Proksch, Peter and Edrada-Ebel, Ruangelie
Item type:Article
ID code:48453
Keywords:animals, Artemia, bacillus subtilis, candida albicans, escherichia coli, Indonesia, microbial sensitivity tests, molecular structure, mollusca, nuclear magnetic resonance, porifera, sesquiterpenes, staphylococcus aureus, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:06 Jun 2014 09:15
Last modified:18 Oct 2019 03:49
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URI:https://strathprints.strath.ac.uk/id/eprint/48453
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