New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata
Yasman, Yasman and Edrada, Ru Angelie and Wray, Victor and Proksch, Peter and Edrada-Ebel, Ruangelie (2003) New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata. Journal of Natural Products, 66 (11). pp. 1512-1514. ISSN 0163-3864
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Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC(50) of 5 ppm. At a dose level of 20 microg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.
Creators(s): | Yasman, Yasman, Edrada, Ru Angelie, Wray, Victor, Proksch, Peter and Edrada-Ebel, Ruangelie; | Item type: | Article |
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ID code: | 48453 |
Keywords: | animals, Artemia, bacillus subtilis, candida albicans, escherichia coli, Indonesia, microbial sensitivity tests, molecular structure, mollusca, nuclear magnetic resonance, porifera, sesquiterpenes, staphylococcus aureus, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 06 Jun 2014 09:15 |
Last modified: | 20 Jan 2021 21:19 |
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URI: | https://strathprints.strath.ac.uk/id/eprint/48453 |
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