New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis
Hassan, Wafaa and Edrada, RuAngelie and Ebel, Rainer and Wray, Victor and Berg, Albrecht and van Soest, Rob and Wiryowidagdo, Sumali and Proksch, Peter and Edrada-Ebel, Ruangelie (2004) New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis. Journal of Natural Products, 67 (5). pp. 817-822. ISSN 0163-3864
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Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.
Creators(s): | Hassan, Wafaa, Edrada, RuAngelie, Ebel, Rainer, Wray, Victor, Berg, Albrecht, van Soest, Rob, Wiryowidagdo, Sumali, Proksch, Peter and Edrada-Ebel, Ruangelie; | Item type: | Article |
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ID code: | 48437 |
Keywords: | alkaloids, antifungal agents, antineoplastic agents, artemia, cladosporium, drug screening assays, imidazoles, Indonesia, mass spectrometry, microbial sensitivity tests, molecular structure, nuclear magnetic resonance, porifera, tumor cells, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 05 Jun 2014 12:04 |
Last modified: | 01 Jan 2021 10:57 |
URI: | https://strathprints.strath.ac.uk/id/eprint/48437 |
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