New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

Hassan, Wafaa and Edrada, RuAngelie and Ebel, Rainer and Wray, Victor and Berg, Albrecht and van Soest, Rob and Wiryowidagdo, Sumali and Proksch, Peter and Edrada-Ebel, Ruangelie (2004) New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis. Journal of Natural Products, 67 (5). pp. 817-822. ISSN 0163-3864

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Abstract

Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

Author(s):Hassan, Wafaa, Edrada, RuAngelie, Ebel, Rainer, Wray, Victor, Berg, Albrecht, van Soest, Rob, Wiryowidagdo, Sumali, Proksch, Peter and Edrada-Ebel, Ruangelie
Item type:Article
ID code:48437
Keywords:alkaloids, antifungal agents, antineoplastic agents, artemia, cladosporium, drug screening assays, imidazoles, Indonesia, mass spectrometry, microbial sensitivity tests, molecular structure, nuclear magnetic resonance, porifera, tumor cells, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:05 Jun 2014 12:04
Last modified:30 Aug 2019 03:20
URI:https://strathprints.strath.ac.uk/id/eprint/48437
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