New beta-carboline alkaloids from the Andaman Sea sponge Dragmacidon sp
Pedpradab, Suwigarn and Edrada, RuAngelie and Ebel, Rainer and Wray, Victor and Proksch, Peter and Edrada-Ebel, Ruangelie (2004) New beta-carboline alkaloids from the Andaman Sea sponge Dragmacidon sp. Journal of Natural Products, 67 (12). pp. 2113-2116. ISSN 0163-3864
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Chemical investigation of the hithertho undescribed sponge Dragmacidon sp. from the Andaman Sea afforded two new beta-carboline alkaloids, which were named dragmacidonamines A (1) and B (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H detected direct, and long-range 13C-1H correlations) and mass spectrometric (EI and ESIMS) data. The 3-carboxylic-beta-carboline moiety and the thiomethylated imidazolinium unit as found in dragmacidonamines are very rarely encountered in nature.
Creators(s): | Pedpradab, Suwigarn, Edrada, RuAngelie, Ebel, Rainer, Wray, Victor, Proksch, Peter and Edrada-Ebel, Ruangelie; | Item type: | Article |
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ID code: | 48436 |
Keywords: | alkaloids, carbolines, nuclear magnetic resonance, oceans and seas, porifera, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology |
Subjects: | Medicine > Therapeutics. Pharmacology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 05 Jun 2014 12:02 |
Last modified: | 01 Jan 2021 10:57 |
URI: | https://strathprints.strath.ac.uk/id/eprint/48436 |
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