Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum

Dai, Hao-Fu and Edrada, Ru Angelie and Ebel, Rainer and Nimtz, Manfred and Wray, Victor and Proksch, Peter and Edrada-Ebel, Ruangelie (2005) Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum. Journal of Natural Products, 68 (8). pp. 1231-1237. ISSN 0163-3864

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Abstract

Along with five known 30-norlanostane-type saponins, sarasinosides A(1) (5A), A3 (6A), I1 (7), I2 (8), and H2 (9), four new triterpenoidal saponin congeners, sarasinosides J (1), K (2), L (3), and M (4), were isolated from the Indonesian sponge Melophlus sarassinorum. Sarasinosides J (1) and K (2) are the 24,25-hydrogenated congeners of the previously described sarasinosides A1 and H2, respectively. The carbon skeleton of sarasinoside M (4) possesses a rearranged 8alpha,9alpha-epoxy-8,9-seconorlanosta-8(14),9(11),24-triene system, which is novel and unprecedented in nature. The structures of the new compounds were confirmed by spectral analyses, chemical derivatization, and GC analyses. Compounds 1 and 5A exhibited antimicrobial activity toward Bacillus subtilis and Saccharomyces cerevisiae.

Author(s):Dai, Hao-Fu, Edrada, Ru Angelie, Ebel, Rainer, Nimtz, Manfred, Wray, Victor, Proksch, Peter and Edrada-Ebel, Ruangelie
Item type:Article
ID code:48433
Keywords:anti-bacterial agents, antifungal agents, bacillus subtilis, chromatography, glycosides, lanosterol, microbial sensitivity tests, molecular structure, nuclear magnetic resonance, porifera, saccharomyces cerevisiae, stereoisomerism, triterpenes, Therapeutics. Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects:Medicine > Therapeutics. Pharmacology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:05 Jun 2014 11:17
Last modified:28 Jun 2019 02:22
URI:https://strathprints.strath.ac.uk/id/eprint/48433
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