Picture map of Europe with pins indicating European capital cities

Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia

Ashour, Mohamed and Edrada, RuAngelie and Ebel, Rainer and Wray, Victor and Wätjen, Wim and Padmakumar, K and Müller, Werner E G and Lin, Wen Han and Proksch, Peter and Edrada-Ebel, Ruangelie (2006) Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. Journal of Natural Products, 69 (11). pp. 1547-1553. ISSN 0163-3864

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.