Label-free pathogen detection with sensor chips assembled from peptide nanotubes

De La Rica, Roberto and Mendoza, Ernest and Lechuga, Laura and Matsui, Hiroshi (2008) Label-free pathogen detection with sensor chips assembled from peptide nanotubes. Angewandte Chemie International Edition, 47 (50). 9752–9755. ISSN 1433-7851

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Abstract

A robust viral sensor was developed by bridging a pair of gold electrodes with antibody-coated peptide nanotubes. The nanotubes concentrated the target virus on their surface by molecular recognition between the antibody and the virus (see picture). The nanotubes fit perfectly within the electric field line distribution to enable the extremely sensitive impedimetric detection of viral particles.