Multivalent nanoparticle networks as ultrasensitive enzyme sensors

De La Rica, Roberto and Fratila, Raluca and Szarpak, Anna and Huskens, Jurriaan and Velders, Aldrik (2011) Multivalent nanoparticle networks as ultrasensitive enzyme sensors. Angewandte Chemie International Edition, 50 (25). 5704–5707. ISSN 1433-7851

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Abstract

As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient