A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing
Sangal, Vartul and Burkovski, Andreas and Hunt, Alison C. and Edwards, Becky and Blom, Jochen and Hoskisson, Paul A. (2014) A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing. Infection, Genetics and Evolution, 21. pp. 54-57. ISSN 1567-1348 (https://doi.org/10.1016/j.meegid.2013.10.019)
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The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.
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Item type: Article ID code: 45367 Dates: DateEventJanuary 2014Published5 November 2013Published Online23 October 2013AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 24 Oct 2013 10:19 Last modified: 27 Jul 2024 22:52 URI: https://strathprints.strath.ac.uk/id/eprint/45367